By B. L. A. Carter, J. R. Piggott, E. F. Walton (auth.), J. F. T. Spencer, Dorothy M. Spencer, A. R. W. Smith (eds.)
During the prior few a long time we've witnessed an period of exceptional progress within the box of molecular biology. In 1950 little or no was once recognized of the chemical structure of organic structures, the way within which info used to be trans mitted from one organism to a different, or the level to which the chemical foundation of lifestyles is unified. the image this day is dramatically assorted. we've a nearly bewildering number of details detailing many various points of existence on the molecular point. There nice advances have introduced with them a few breath-taking insights into the molecular mechanisms utilized by nature for rep licating, allotting and enhancing organic details. we have now discovered greatly concerning the chemical and actual nature of the macromolecular nucleic acids and proteins, and the way during which carbohydrates, lipids and smaller molecules interact to supply the molecular atmosphere of residing sys tems. it'd be stated that those few many years have changed a close to vacuum of knowledge with a really huge surplus. it's within the context of this flood of knowledge that this sequence of monographs on molecular biology has been equipped. the assumption is to compile in a single position, among the covers of 1 publication, a concise review of the country of the topic in a well-defined box. this can let the reader to get a feeling of old perspectiv(}-what is understood in regards to the box today-and an outline of the frontiers of analysis the place our wisdom is expanding steadily.
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Extra info for Yeast Genetics: Fundamental and Applied Aspects
H. (1976). Sequential function of gene products relative to DNA synthesis in the yeast cell cyCle. J. Mol. BioI. 104: 803-817. Hartwell, L. H. (1978). Cell division from a genetic perspective. J. Cell BioI. 77: 627637. Hartwell, L. H. (1980). Mutants of Saccharomyces cerevisiae unresponsive to cell division control by polypeptide mating hormone. J. Cell BioI. 85: 811. Hartwell, L. , Unger, M. W. (1977). Unequal division in Saccharomyces cerevisiae and its implications for the control of cell division.
Representative strains carrying other ste gene mutations had normal adenylate cyclase activity. Mutations in ste5 result in nonmating at the restrictive temperature and this phenotype occurs whether the cells are of the a or a mating type. In addition, Liao and Thorner (1980) observed that adenylate cyclase was present in membranes of a haploids and a/a diploids and in both cases was inhibited by a factor. In vivo a factor has no effect on a cells or a/ a diploids. The authors suggest that the biochemical mechanism of a factor action involved its inhibition of the adenylate cyclase in the plasma membrane of a cells.
Multifunctional proteins. Annu. Rev. Biochem. 45: 143-166. Kuenzi, M. T. and Fiechter, A. (1977). Regulation of carbohydrate composition of Saccharomyces cerevisiae under growth limitation. Arch. Mikrobiol. 84: 254-265. Lajtha, L. G. (1963). On the concept of the cell cycle. J. Cell Compo Physiol62: Suppl. 1, pp. 143-144. , Thorner, J. (1980). Yeast mating pheromone a factor inhibits adenylate cyclase. Biochemistry 77: 1898-1902. Lillie, S. , Pringle, J. R. (1980). Reserve carbohydrate metabolism in Saccharomyces cerevisiae: responses to nutrient limitation.
Yeast Genetics: Fundamental and Applied Aspects by B. L. A. Carter, J. R. Piggott, E. F. Walton (auth.), J. F. T. Spencer, Dorothy M. Spencer, A. R. W. Smith (eds.)