By Judith H. Harmey
VEGF and melanoma is a finished and recent assessment of present wisdom at the function of vascular endothelial development issue (VEGF) in melanoma. Key gains: -Discussion of VEGF as effective angiogenic issue and its position in tumor angiogenesis, -Review of the biology, molecular houses and rules of VEGF, -Discussion of the position of VEGF in a number varied tumor varieties, either stable tumors and haematological cancers, -Review of the healing strength of other methods to dam VEGF, -Review of contemporary facts that during addition to its function as an endothelial mobilephone mitogen, VEGF can also be an autocrine development issue for tumor cells, regulating survival and invasion. This booklet is geared toward scientists new to angiogenesis and VEGF biology and gives new details for proven researchers and scientists. it's going to even be an invaluable textual content for clinicians attracted to anti-angiogenic remedy for remedy of human cancers.
Read Online or Download VEGF and Cancer (Medical Intelligence Unit) PDF
Similar oncology books
Greens, entire Grains and their Derivatives in melanoma Prevention appears to be like intimately on the facts concerning the results and mechanisms of motion of probably cancer-preventive elements and their assets from plant country. The publication covers present wisdom on convinced meals and their elements in melanoma prevention, comparable to cruciferous and eco-friendly leafy greens, nuts and seeds, entire grains, tomato lycopene and carotenoids, alliums and their sulphur and selenium ingredients, and capsaicinoids from chilli peppers.
It is a 3-in-1 reference e-book. It provides an entire clinical dictionary masking 1000s of phrases and expressions on the subject of malignant mesothelioma. It additionally provides huge lists of bibliographic citations. ultimately, it presents details to clients on tips to replace their wisdom utilizing quite a few web assets.
This quantity incorporates a selection of writings from the leaders within the fields of Molecular Biology and cancer study so as to start to inform the ever-expanding tale of the newest findings, discoveries, and power of BRAF-directed objectives in cancer. fresh examine has proven that BRAF inhibitors are potent for a brief time period, yet there's little desire that this medications as unmarried brokers will bring about sturdy profit in a majority of sufferers.
Biopsy Interpretation of sentimental Tissue Tumors is a realistic advisor and bench reference for surgical pathologists for the translation of sentimental tissue biopsies, together with open and percutaneous center needle biopsies. each one bankruptcy publications readers in a logical manner, with the major differential diagnostic gains of particular tumors certain inside of every one class, utilizing morphologic, immunohistochemical, ultrastructural, and genetic information.
Additional resources for VEGF and Cancer (Medical Intelligence Unit)
19. Kieser A, Weich HA, Brandner G et al. Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression. Oncogene 1994; 9:963-969. 20. Graeven U, Fiedler W, Karpinski S et al. Melanoma-associated expression of vascular endothelial growth factor and its receptors FLT-1 and KDR. J Cancer Res Clin Oncol 1999; 125:621-629. 21. Shweiki D, Itin A, Soffer D et al. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992; 359:843–845.
An essential role for p300/CBP in the cellular response to hypoxia. Proc Natl Acad Sci USA 1996; 93:12969-12973. 5. Damert A, Ikeda E, Risau W. Activator-protein-1 binding potentiates the hypoxia-induciblefactor1-mediated hypoxia-induced transcriptional activation of vascular-endothelial growth factor expression in C6 glioma cells. Biochem J 1997; 327:419-423. 6. Ryuto M, Ono M, Izumi H et al. Induction of vascular endothelial growth factor by tumor necrosis factor α in human glioma cells. Possible roles of SP-1.
Dimmeler S, Fleming I, Fisslthaler B et al. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 1999; 399:601–605. 49. Rousseau S, Houle F, Kotanides H et al. Vascular endothelial growth factor (VEGF)-driven actin-based motility is mediated by VEGFR2 and requires concerted activation of stress-activated protein kinase (SAPK2/p38) and geldanamycin-sensitive phosphorylation of focal adhesion kinase. J Biol Chem 2000; 275:10661–10672. 50. Ziche M, Morbidelli L, Masini E et al.
VEGF and Cancer (Medical Intelligence Unit) by Judith H. Harmey