Read e-book online VEGF and Cancer (Medical Intelligence Unit) PDF

By Judith H. Harmey

ISBN-10: 0306479885

ISBN-13: 9780306479885

ISBN-10: 1417562250

ISBN-13: 9781417562251

VEGF and melanoma is a finished and recent assessment of present wisdom at the function of vascular endothelial development issue (VEGF) in melanoma. Key gains: -Discussion of VEGF as effective angiogenic issue and its position in tumor angiogenesis, -Review of the biology, molecular houses and rules of VEGF, -Discussion of the position of VEGF in a number varied tumor varieties, either stable tumors and haematological cancers, -Review of the healing strength of other methods to dam VEGF, -Review of contemporary facts that during addition to its function as an endothelial mobilephone mitogen, VEGF can also be an autocrine development issue for tumor cells, regulating survival and invasion. This booklet is geared toward scientists new to angiogenesis and VEGF biology and gives new details for proven researchers and scientists. it's going to even be an invaluable textual content for clinicians attracted to anti-angiogenic remedy for remedy of human cancers.

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19. Kieser A, Weich HA, Brandner G et al. Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression. Oncogene 1994; 9:963-969. 20. Graeven U, Fiedler W, Karpinski S et al. Melanoma-associated expression of vascular endothelial growth factor and its receptors FLT-1 and KDR. J Cancer Res Clin Oncol 1999; 125:621-629. 21. Shweiki D, Itin A, Soffer D et al. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992; 359:843–845.

An essential role for p300/CBP in the cellular response to hypoxia. Proc Natl Acad Sci USA 1996; 93:12969-12973. 5. Damert A, Ikeda E, Risau W. Activator-protein-1 binding potentiates the hypoxia-induciblefactor1-mediated hypoxia-induced transcriptional activation of vascular-endothelial growth factor expression in C6 glioma cells. Biochem J 1997; 327:419-423. 6. Ryuto M, Ono M, Izumi H et al. Induction of vascular endothelial growth factor by tumor necrosis factor α in human glioma cells. Possible roles of SP-1.

Dimmeler S, Fleming I, Fisslthaler B et al. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 1999; 399:601–605. 49. Rousseau S, Houle F, Kotanides H et al. Vascular endothelial growth factor (VEGF)-driven actin-based motility is mediated by VEGFR2 and requires concerted activation of stress-activated protein kinase (SAPK2/p38) and geldanamycin-sensitive phosphorylation of focal adhesion kinase. J Biol Chem 2000; 275:10661–10672. 50. Ziche M, Morbidelli L, Masini E et al.

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VEGF and Cancer (Medical Intelligence Unit) by Judith H. Harmey


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