By Richard Mithen, Charlotte Armah, Maria Traka (auth.), Marja Mutanen, Anne-Maria Pajari (eds.)
Vegetables, complete Grains and their Derivatives in melanoma Prevention seems to be intimately on the facts in regards to the results and mechanisms of motion of probably cancer-preventive elements and their resources from plant nation. The publication covers present wisdom on sure meals and their parts in melanoma prevention, comparable to cruciferous and eco-friendly leafy greens, nuts and seeds, entire grains, tomato lycopene and carotenoids, alliums and their sulphur and selenium elements, and capsaicinoids from chilli peppers. It focuses not just on unmarried compounds yet goals to widen the view by means of discussing a whole-diet process in melanoma prevention. A unmarried part might lose its chemopreventive efficacy whilst remoted from the meals matrix and in lots of situations remoted and focused parts as supplementations may very well set off tumor improvement. except describing the results and mechanisms of motion, the chapters additionally comprise details on consumption, bioavailability, metabolism and attainable poisonous results of meals and elements offered. evaluate and comparability of the knowledge from mechanistic reviews in vitro with these from animal experiments in vivo shape a foundation for making use of the present wisdom to human foodstuff within the box of carcinogenesis. With contributions from major specialists within the box, this ebook is a useful source for scientists and pros operating in melanoma examine, in addition to participants concerned with foodstuff and nutrition.
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Greens, entire Grains and their Derivatives in melanoma Prevention seems to be intimately on the proof in regards to the results and mechanisms of motion of probably cancer-preventive elements and their resources from plant state. The ebook covers present wisdom on convinced meals and their materials in melanoma prevention, resembling cruciferous and eco-friendly leafy greens, nuts and seeds, entire grains, tomato lycopene and carotenoids, alliums and their sulphur and selenium materials, and capsaicinoids from chilli peppers.
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Extra resources for Vegetables, Whole Grains, and Their Derivatives in Cancer Prevention
DNA Cell Biol 12:1–51 Neuhouser ML, Patterson RE, Thornquist MD et al (2003) Fruits and vegetables are associated with lower lung cancer risk only in the placebo arm of the beta-carotene and retinol efficacy trial (CARET). Cancer Epidemiol Biomarkers Prev 12:350–358 Nogales E (1999) A structural view of microtubule dynamics. Cell Mol Life Sci 56:133–142 Nyberg F, Agrenius V, Svartengren K et al (1998) Dietary factors and risk of lung cancer in neversmokers. Int J Cancer 78:430–436 Parnaud G, Li P, Cassar G et al (2004) Mechanism of sulforaphane-induced cell cycle arrest and apoptosis in human colon cancer cells.
2004). In contrast, isothiocyanate treatment on prostate PC-3 and bladder UM-UC-3 cells resulted in reduced expression of Cyclin B1 (Singh et al. 2004b; Tang and Zhang 2004). The G2/M phase arrest in PC-3 cells activated the DNA damage checkpoint pathway through activation of checkpoint kinase 2 (Chk2) and subsequent phosphorylation of cell division cycle 25C (Singh et al. 2004b). Finally, S-phase arrest reported in UM-UC-3 cells in response to isothiocyanates treatment was also associated with reduced levels of Cyclin A (Tang and Zhang 2004).
Cell Mol Life Sci 59:2004–2012 Firestone GL, Sundar SN (2009) Minireview: modulation of hormone receptor signaling by dietary anticancer indoles. Mol Endocrinol 23:1940–1947 Foo HL, Gronning LM, Goodenough L et al (2000) Purification and characterisation of epithiospecifier protein from Brassica napus: enzymic intramolecular sulphur addition within alkenyl thiohydroximates derived from alkenyl glucosinolate hydrolysis. FEBS Lett 468: 243–246 Fowke JH, Chung FL, Jin F et al (2003) Urinary isothiocyanate levels, brassica, and human breast cancer.
Vegetables, Whole Grains, and Their Derivatives in Cancer Prevention by Richard Mithen, Charlotte Armah, Maria Traka (auth.), Marja Mutanen, Anne-Maria Pajari (eds.)