Read e-book online Vaccine Adjuvants: Immunological and Clinical Principles PDF

By Charles J. Hackett, Donald A. Harn Jr

ISBN-10: 0896038920

ISBN-13: 9780896038929

ISBN-10: 1592599702

ISBN-13: 9781592599707

A state-of-the-art assessment of the key learn parts of adjuvant discovery, layout, improvement, and use. The authors lay down a rational foundation for vaccine adjuvant functionality and study a few considerably exact adjuvant-active molecules to light up the rules in their functionality and use. the point of interest is on particular receptor-ligand interactions, together with the molecular positive aspects wanted for a compound to own adjuvant task. The serious interface region among the innate and adaptive immune platforms can also be analyzed to teach how adjuvants exert their results on T- and B-cell activation. extra chapters handle the potential for tailoring adjuvants to yield optimally secure and powerful responses.

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Fed Proc Transl Suppl 1965;24:500–506. 22 Beutler 103. Grinstein S, Kierszenbaum F, Ferraresi RW. The adjuvant action of Escherichia coli lipopolysaccharide and of its lipid fraction on antibody production. Rev Immunol Ther Antimicrob 1966;30:141–149. 104. Neter E. Endotoxins and the immune response. Curr Top Microbiol Immunol 1969; 47:82–124. 105. Berger FM. The effect of endotoxin on resistance to infection and disease. Adv Pharmacol 1967;5:19–46. 106. Skidmore BJ, Chiller JM, Weigle WO. Immunologic properties of bacterial lipopolysaccharide LPS.

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Vaccine Adjuvants: Immunological and Clinical Principles (Infectious Disease) by Charles J. Hackett, Donald A. Harn Jr


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