By Price, Pat
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Additional resources for Treatment of Cancer Fifth Edition
5 Predicted new drug application (NDA) dates for molecular therapies in the USA. The years 2005–2010 will see an explosion of novel therapies coming into clinical use outside a research setting. 6 In future cancer drugs will be administered to patients accompanied with effective biomarkers. These will lead to novel surrogate markers of response. This will change the dynamic of the phase I, phase II and phase III studies currently used in cancer drug development. PD pharmacodynamic; sNDA supplementary new drug application; CRO contract research organisation; MTD maximum tolerable dose The future – getting innovation into practice 13 This traditional approach may not be appropriate for many of our new agents.
Major innovations in the following six areas are likely to have the greatest impact on cancer. 1. Molecularly targeted drugs with associated sophisticated diagnostic systems to personalize care. 2. Biosensors to detect, monitor and correct abnormal physiology and to provide surrogate measurements of cancer risk. 3. Our ability to modify the human genome through systemically administered, novel, targeted vectors. 4. The continued miniaturization of surgical intervention through robotics, nanotechnology and precise imaging.
The role of industry in the development of new therapies will continue to change. Smaller, more specialized companies linked to universities will increasingly deliver drug candidates and innovative diagnostics to the large commercially driven multinational pharmaceutical companies who will market them globally. People will be used to living with risk and will have much more knowledge about their propensity for disease. Programmes will enable them to determine their own predisposition to cancer.
Treatment of Cancer Fifth Edition by Price, Pat