By Yun-Fai Chris Lau, Wai-Yee Chan
The final touch of the human genome and technological advances built through the Human Genome venture have dramatically replaced our realizing of the mechanisms underlying the advance and differentiation of male germ cells, and our skill to enquire such mechanisms. This publication is a well timed rfile of advances made within the box of male gonad and germ cellphone examine within the postgenomic period. The assurance comprises the position of Y chromosome genes in male replica, gene expression in spermatogonial stem cells and male germ cells, and the law of germ phone genes in replica and in germ mobile tumors.
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Extra info for The Y chromosome and male germ cell biology in health and diseases
An increased level of sperm abnormalities in mice with a partial deletion of the Y chromosome. Genet Res 57, 195–199. , and Krzanowska, H. (2003). Inﬂuence of the CBA genetic background on sperm morphology and fertilization efﬁciency in mice with a partial Y chromosome deletion. Reproduction 126, 579–588. , and Moriwaki, K. (1991b). Inﬂuence of partial deletion of the Y chromosome on mouse sperm phenotype. J Reprod Fertil 92, 187–195. Sutcliffe, M. , and Burgoyne, P. S. (1989). Analysis of the testes of H-Y negative XOSxrb mice suggests that the spermatogenesis gene (Spy) acts during the differentiation of the A spermatogonia.
S. , 1996). 5 dpc. Both studies found that paternal XCI begins much earlier; but while Okamoto et al. (2004) reported the timing of initiation as being between the 4- and 8-cell stage, Huynh and Lee (2003) found evidence of paternal X chromosome silencing at the 2-cell stage. In light of their ﬁndings, Huynh and Lee (2003) proposed that the paternal X chromosome arrives in the female embryo in an already inactive state, and that MSCI might therefore have been co-opted as a mechanism of dosage compensation in the preimplantation embryo.
Science 286, 964–967. Laval, S. , Glenister, P. , Thornton, C. , Mahadevaiah, S. , Cooke, H. , Burgoyne, P. , and Cattanach, B. M. (1995). Y chromosome short arm-Sxr recombination in XSxr/Y males causes deletion of Rbm and XY female sex reversal. Proc Natl Acad Sci U S A 92, 10403–10407. , Kim, S. , Chung, S. , Wolgemuth, D. , and Rhee, K. (2004). Developmental stage-speciﬁc expression of Rbm suggests its involvement in early phases of spermatogenesis. Mol Hum Reprod 10, 259–264. , and Hunt, P.
The Y chromosome and male germ cell biology in health and diseases by Yun-Fai Chris Lau, Wai-Yee Chan