By Doretta Caramaschi
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Extra resources for The physiology of aggression: towards understanding violence
Are violent mouse types physiologically similar to violent humans? – in which specific type of mouse aggression is serotonin involved, if it is involved at all? – is the serotonin-1A receptor involved in aggression and violence? In Chapter 2 I investigate the behavioural phenotype of the three pairs of mouse selection lines with respect to non-social proactive behaviours and activity/exploration. In Chapter 3 I investigate the possibility of identifying a violent behavioural phenotype in the mouse lines selected for high and low aggressiveness.
However, recent studies show that there are individual differences in the vulnerability to diseases and in the response to pharmacological treatments, and that in several cases these differences are related to different personalities (Mehta and Gosling 2008). Moreover, in the study of human aggression, it is worth mentioning that aggressiveness may be typical of certain personalities (Ramirez and Andreu 2006) and differential neurobiological mechanisms may be behind these relationships (Siever, 2008).
In this thesis, I investigate the peripheral physiology of the six mouse lines for the first time in the same experiments (see Chapters 4 and 5). Since testosterone is generally known to correlate positively with aggressiveness, researchers have investigated the neuroendocrine circuit in which testosterone is involved. , 1987). , 1993). , 1993). , 1994b). , 1993a). , 1968) and not much more research has been done on this topic in these lines. , 1996). Typical neurochemical systems involved in the control of aggression are serotonin, dopamine, γ-aminobutiric acid (GABA) and noradrenaline.
The physiology of aggression: towards understanding violence by Doretta Caramaschi