New PDF release: The M.D. Anderson Surgical Oncology Handbook 4th Edition

By M.D. Anderson Cancer Center Department of Surgical Oncology, Barry W Feig, David H Berger, George M

ISBN-10: 078175643X

ISBN-13: 9780781756433

Written via present and previous surgical oncology fellows of the world-renowned M.D. Anderson melanoma middle, this moveable guide is a pragmatic consultant to demonstrated surgical oncology ideas for every organ procedure. This new Fourth version positive factors wide updates together with new chapters on reconstructive surgical procedure within the melanoma sufferer. Concise chapters illustrated with algorithms and line drawings define the basic components of analysis, staging, and scientific administration of strong tumors taken care of in surgical perform. The authors emphasize multidisciplinary therapy making plans, together with treatment sequencing and biologic treatments.

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Extra resources for The M.D. Anderson Surgical Oncology Handbook 4th Edition

Sample text

Approximately 10% to 20% of all patients with breast cancer have stage III disease, which includes T3 tumors with N1, N2, or N3 disease; T4 tumors with any N classification; or any T classification with N2 or N3 regional lymph node involvement. Approximately 25% to 30% of stage III breast cancers are inoperable at the time of diagnosis. Many locally advanced breast cancers are discovered by a patient or her spouse. The remaining are discovered during routine physical examination. On occasion, a discrete mass may not be present; rather, there is a diffuse infiltration of the breast tissue.

SLN biopsy can be performed using radiolabeled colloid, vital blue dye, or both. Preoperative lymphoscintigraphy, although not mandatory, can be used to identify the SLN and document patterns of lymphatic drainage. A handheld gamma counter, the aid of visible blue dye, or both can be used intraoperatively to locate the SLN. SLN biopsy may be unsuccessful in patients with certain clinical presentations: (a) palpable axillary adenopathy, (b) medial hemisphere location of the primary tumor where preoperative lymphoscintigraphy did not identify an axillary SLN, (c) previous axillary surgery because the lymphatic drainage from the primary may be distorted, and (d) large biopsy cavity (larger than 6 cm) because the lymphatic drainage from the surrounding breast tissue may not be the same as that of the primary tumor.

The Halsted radical mastectomy, which was initially believed to be the treatment of choice for locally advanced breast cancer, has been proven to be inadequate for local control and long-term patient survival. In 1942, Haagensen reported a 53% local recurrence rate and a 0% 5-year overall survival rate among 1,135 patients with stage III breast cancer who had undergone a Halsted radical mastectomy. The failure of surgery alone to control stage III breast cancer led to the use of radiation therapy as a single-agent treatment modality in this group of patients.

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The M.D. Anderson Surgical Oncology Handbook 4th Edition by M.D. Anderson Cancer Center Department of Surgical Oncology, Barry W Feig, David H Berger, George M


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