By Douglas Hanahan, Robert A. Weinberg
Read Online or Download The Hallmarks of Cancer PDF
Similar oncology books
Greens, entire Grains and their Derivatives in melanoma Prevention seems intimately on the proof in regards to the results and mechanisms of motion of doubtless cancer-preventive elements and their assets from plant state. The publication covers present wisdom on yes meals and their parts in melanoma prevention, corresponding to cruciferous and eco-friendly leafy greens, nuts and seeds, entire grains, tomato lycopene and carotenoids, alliums and their sulphur and selenium materials, and capsaicinoids from chilli peppers.
It is a 3-in-1 reference ebook. It offers a whole scientific dictionary masking hundreds and hundreds of phrases and expressions on the subject of malignant mesothelioma. It additionally offers broad lists of bibliographic citations. eventually, it offers details to clients on how you can replace their wisdom utilizing a number of web assets.
This quantity includes a choice of writings from the leaders within the fields of Molecular Biology and cancer learn as a way to start to inform the ever-expanding tale of the latest findings, discoveries, and power of BRAF-directed objectives in cancer. contemporary learn has proven that BRAF inhibitors are potent for a brief time period, yet there's little wish that this medicines as unmarried brokers will bring about sturdy gain in a majority of sufferers.
Biopsy Interpretation of soppy Tissue Tumors is a realistic consultant and bench reference for surgical pathologists for the translation of soppy tissue biopsies, together with open and percutaneous center needle biopsies. each one bankruptcy publications readers in a logical approach, with the main differential diagnostic positive factors of particular tumors special inside of every one class, utilizing morphologic, immunohistochemical, ultrastructural, and genetic info.
Extra info for The Hallmarks of Cancer
Corbalan-Garcia, S. (2001). Identification of the Phosphatidylserine Binding Site in the C2 Domain that Is Important for PKCalpha Activation and in Vivo Cell Localization. Biochemistry, 40(46), 13898–13905. C. (2007). The C2 domains of classical/conventional PKCs are specific PtdIns(4,5)P(2)-sensing domains. Biochemical Society Transactions, 35(Pt 5), 1046–1048. C. (2007). A single residue in the C1 domain sensitizes novel protein kinase C isoforms to cellular diacylglycerol production. The Journal Biologica Chemistry, 282(2), 826–830.
Biochemistry, 37(35), 12020–12025. , Wong. , et al. (1994). Zinc Finger Domains and Phorbol Ester Pharmacophore: Analysis of binding to mutated form of protein kinase C z and the vav and c-raf proto-oncogene products. The Journal Biological Chemistry, 269, 11590–11594. C. C. (1995). Protein kinase C is regulated in vivo by three functionally distinct phosphorylations. Current Biology, 5(12), 1394–1403. , et al (2003). Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins.
2008). The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail. The Journal of Biological Chemistry, 284(8), 4921–4835. C. (2008). The life and death of protein kinase C. Current Drug Targets, 9(8), 614–625. G. (2007). Protein kinase C and other diacylglycerol effectors in cancer. Nature Reviews. Cancer, 7(4), 281–294. , et al. (2006). Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.
The Hallmarks of Cancer by Douglas Hanahan, Robert A. Weinberg