By Helen E. Scharfman
The dentate gyrus is part of the mind that has been a subject of excessive curiosity because the starting of neuroscience, and pioneering experiences from the far-off and up to date earlier attest to this. one of many purposes for such curiosity is this constitution offers one of the most awesome examples of plasticity in the fearful method. furthermore, it's severe to common cognitive functionality, even though precisely how and while continues to be a question that eludes solutions. additionally, abnormalities in the dentate gyrus seem to play a task in assorted scientific stipulations, from melancholy to epilepsy and nerve-racking mind damage. the first target of this booklet is to supply a context, or historical past, upon which the specified wisdom of the present period might be liked. a chain of overviews are supplied to elucidate necessities on the topic of structural association and improvement, mobile elements, neurotransmitters and neuromodulators, plasticity, and medical relevance. * Covers the subject comprehensively from anatomy to mobile and platforms views* contains uncomplicated learn and addresses translational implications, so it is going to be necessary to either researchers within the laboratory and clinicians who behavior experiments in people* Chapters supply basics, but additionally info and considerable references for additional evaluate of the subject
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Additional info for The Dentate Gyrus: A Comprehensive Guide to Structure, Function, and Clinical Implications
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A prototypical pyramidal basket cell is shown after intracellular injection of Neurobiotin. The montage that was created after visualization of the cell (A) and line drawing (B) illustrate the characteristics of this cell type. An arrow points to the axon. Calibration bar ¼ 25 mm (A), 40 mm (B). 13 Fig. 8. The mossy cell. A line drawing of a mossy cell (mc) in the polymorphic layer. The axon (arrow) develops a plexus within the polymorphic layer, and also an ipsilateral projection to the inner molecular layer, known as the associational pathway.
While thorny excrescences are also observed on the proximal dendrites of CA3 pyramidal cells, they are never as dense or as complex as the ones on the mossy cells. The distal dendrites of the mossy cell have typical pedunculate spines that appear to be less dense than those on the distal dendrites of the hippocampal pyramidal cells. Mossy cell projections The inner third of the molecular layer (Fig. , 1992, 1996). Since, in the rat, this projection originates both in the ipsilateral and contralateral sides of the dentate gyrus, it has been called the associational/commissural projection.
The Dentate Gyrus: A Comprehensive Guide to Structure, Function, and Clinical Implications by Helen E. Scharfman