Read e-book online The Centrosome in Cell Replication and Early Development PDF

By Robert E. Palazzo, Gerald P. Schatten

ISBN-10: 012153149X

ISBN-13: 9780121531492

Centrosomes play an critical position within the development of cells and the last word improvement of many animals, and infrequently vegetation. as well as the traditional progress of cells, centrosomes may also play a key function within the unfold of melanoma and are of elevated curiosity to either the genetics and oncology groups. Volume 49 of Current subject matters in Developmental Biology will current all identified examine surrounding the centrosome, throughout various structures, might be good referenced, and speculate the place the learn is headed.

Key Features
* Discusses centrosomes and melanoma, centrosomes and early improvement, and molecular biology of the centrosome
* seriously illustrated, with many colour figures
* Chapters written through foreign leaders within the box

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Extra resources for The Centrosome in Cell Replication and Early Development

Sample text

D. (1997b). Actomyosin-based retrograde flow of microtubules in the lamella of migrating epithelial cells influences microtubule dynamic instability and turnover and is associated with microtubule breakage and treadmilling. J. Cell Biol. 139, 417–434. Waters, J. , and Salmon, E. D. (1997). Pathways of spindle assembly. Curr. Opin. Cell Biol. 9, 37–43. , Skalhegg, B. , and Orstavik, S. (1999). Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450.

Although the role of many centrosomal proteins in microtubule assembly remains open to debate and further study, many lines of evidence (discussed in Section IV and elsewhere in this volume) lead to the inescapable conclusion that Ͳ-tubulin is important for assembly of microtubules from centrosomes and other MTOCs. II. ␥-Tubulin and the Tubulin Superfamily of Proteins Ͳ-Tubulin was discovered in a screen for suppressors of a ͱ-tubulin mutation in the filamentous fungus Aspergillus nidulans (Oakley and Oakley, 1989).

B) A tubulin dimer (arrowhead) binds to the Ͳ-TuRC and the binding is stabilized by interaction with Ͳ-tubulin and the adjacent tubulin dimer. (c) Additional dimers bind until in (d), a complete B-lattice microtubule is formed. Modified from Oakley (1995). Reproduced by permission. Ͳ-TuRCs than they have for each other. Tubulin dimers, thus, bind to Ͳ-TuRCs, creating a layer of tubulin dimers. Additional dimers bind and a microtubule is formed. A template model such as the one shown would also explain how microtubule polarity is established by the centrosome.

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The Centrosome in Cell Replication and Early Development by Robert E. Palazzo, Gerald P. Schatten


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