Download e-book for kindle: The CDK-Activating Kinase (CAK) by Philipp Kaldis

By Philipp Kaldis

ISBN-10: 0306474387

ISBN-13: 9780306474385

ISBN-10: 1587060566

ISBN-13: 9781587060564

This quantity goals to extract and summarize all information regarding CAK through mentioning more often than not permitted evidence and unresolved concerns. It takes the reader from yeast to mammals and describes all parts that CAK is assumed to be taken with. This quantity is designed to serve beginners to the sphere in addition to experts; anybody drawn to telephone progress, sign transduction and melanoma will locate this a great tool to possess.

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Extra info for The CDK-Activating Kinase (CAK)

Example text

WAF1, a potent mediator of p53 tumor suppression. Cell 1993; 75:817-825. 35. Gu Y, Turck CW, Morgan DO. Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit. Nature 1993; 366:707-710. 36. Harper JW, Adami GR, Wei N, Keyomarski K, Elledge SJ. The p21 cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 1993; 75:805-816. 37. Polyak K, Kato J-y, Solomon MJ, Sherr CJ, Massagué J, Roberts JM et al. p27Kip1, a cyclincdk inhibitor, links transforming growth factor-β and contact inhibition to cell cycle arrest.

These data suggest that the level of Cak1p protein during sporulation is regulated not only at the transcriptional level but also by a developmentally regulated proteolysis pathway. Subsequently Cak1p levels increase as middle genes are transcriptionally induced, and as cells exit pachytene and enter the meiotic divisions. Since Cak1p is required for Cdc28p activity and Cdc28p is rate limiting for exit from pachytene this might suggest that the regulation of Cak1p levels could play a role in the pachytene checkpoint.

Mol Cell Biol 1998; 18:2923-2931. 83. Adamczewski JP, Rossignol M, Tassan J-P, Nigg EA, Moncollin V, Egly J-M. MAT1, cdk7 and cyclin H form a kinase complex which is UV light-sensitive upon association with TFIIH. EMBO J 1996; 15:1877-1884. 84. Roy R, Adamczewski JP, Seroz T, Vermeulen W, Tassan J-P, Schaeffer L et al. The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor. Cell 1994; 79:1093-1101. 85. Serizawa H, Mäkelä TP, Conaway JW, Conaway RC, Weinberg RA, Young RA.

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The CDK-Activating Kinase (CAK) by Philipp Kaldis


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