By Seymour H. Levitt, James A. Purdy, Carlos A. Perez, Philip Poortmans
This booklet is exclusive in detailing intensive the technological foundation of radiation remedy. in comparison with the former variation, all chapters were rewritten and up to date. additionally, new chapters were integrated on a variety of subject matters, together with using imaging in therapy making plans, moment malignant neoplasms because of irradiation, and caliber coverage in radiation oncology. The publication is split into sections. the 1st covers simple options in remedy making plans and explains many of the methods to radiation treatment. the second one half records the sensible scientific functions of those ideas within the remedy of other cancers.
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Additional info for Technical Basis of Radiation Therapy: Practical Clinical Applications (Medical Radiology Radiation Oncology)
Int J Radiat Oncol Biol Phys 10:593–598 Turesson I, Notter G (1984b) The influence of the overall treatment time in radiotherapy on the acute reaction: comparison of the effects of daily and twice-a-week fractionation on human skin. Int J Radiat Oncol Biol Phys 10:607–619 Van de Geijn J (1989) Incorporating the time factor into the linear-quadratic model (letter). Br J Radiol 62:296–2988 Van Dyk J, Mah k, Keane T (1989) Radiation-induced lung damage; dose-time fractionation considerations. Radiother Oncol 14:55–69 Vargas C, Kestin LL, Martinez AA et al (2003) Dose-volume analysis of predictors fpr chronic rectal toxicity following treatment of prostate cancer with high-dose conformal 31 radiotherapy (ASTRO abstract # 2093).
2003; Fowler et al. 2003b). Only recently have clinical results of good tumor control begun to mature at the 5-year follow-up required to be entirely convincing (Livsey et al. 2003; Lukka et al. 2003; Chappell and Fowler 2004). 5 Gy. At the same time, evidence is also accumulating that the DE ratio for late complications in rectum might be greater than the usually assumed value of 3 Gy, perhaps about 5 Gy (Brenner 2004). Clinical results will resolve this issue within a few years, but the use 23 of hypofractionation for prostate cancer appears to be a unique opportunity to obtain both better tumor control and economy of resources.
6 Gy; Leborgne et al. 2 logs in 33 days on our scale. A few schedules use shorter overall times of 3 weeks or 4 weeks, together with reduced total doses so that their predicted late complications should also be less. These include Gortec II (Baumann et al. 2002; Bourhis et al. 1 log10 in 24 days, Manchester’s traditional 16 fractions (Slevin et al. 0 log10 in 21 days at its 54 Gy level. Since the present modeling assumed Tk=21 days for this chapter, no theoretical advantage is shown for times shorter than 3 weeks.
Technical Basis of Radiation Therapy: Practical Clinical Applications (Medical Radiology Radiation Oncology) by Seymour H. Levitt, James A. Purdy, Carlos A. Perez, Philip Poortmans