Download e-book for kindle: Sox2 : biology and role in development and disease by Hisato Kondoh, Robin Lovell-Badge

By Hisato Kondoh, Robin Lovell-Badge

ISBN-10: 0128003529

ISBN-13: 9780128003527

ISBN-10: 0128004207

ISBN-13: 9780128004203

Sox2: Biology and position in improvement and ailment offers a radical dialogue of the $64000 position of Sox2 in mobile and developmental strategies, geared toward facilitating larger realizing of the way Sox2 services throughout diverse disciplines. The ebook discusses the fundamental biology of Sox2 to assist determine the serious foundational wisdom helpful for deeper molecular and useful research. The publication additionally presents perception into how the Sox2 transcription issue performs a key function in pluripotency induction, upkeep, and development.

Helpful as a device to arrange new study initiatives, the publication assists with getting ready classes, seminars, and thesis or examine papers, thereby circumventing the necessity to spend hours looking through magazine databases. A unmarried resource for the fundamental biology of Sox2, Sox2: Biology and Its position in improvement and Disease presents info on networks, gene law, and regulatory functionality in a couple of telephone kinds and tissues types.

  • Discusses the real position of Sox2 in mobile and developmental processes
  • Facilitates a better figuring out of ways Sox2 features throughout various disciplines
  • Assists in making a choice on, circumventing and enhancing the dynamics of Sox2 in mobilephone types
  • Provides better figuring out of the constitution of Sox2 and its gene networks
  • Identifies points of phenotypic spectrum exposed following larger knowing of Sox2 in the course of development

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Extra info for Sox2 : biology and role in development and disease

Sample text

J. Cell. Physiol. 186, 315–328. , 2008. Global jumping and domain-specific intersegment transfer between DNA cognate sites of the multidomain transcription factor Oct-1. Proc. Natl. Acad. Sci. A. 105, 13871–13876. , 2003. EDTA-derivatized deoxythymidine as a tool for rapid determination of protein binding polarity to DNA by intermolecular paramagnetic relaxation enhancement. J. Am. Chem. Soc. 125, 6634–6635. , 2006a. Detecting transient intermediates in macromolecular binding by paramagnetic NMR.

The pre-miRNA is subsequently exported from the nucleus into the cytoplasm by EXPORTIN-5 (XPO5, also known as EXP5) in a complex with RAN-GTP via the nuclear pore complex. In the cytoplasm, the pre-miRNA is bound by the dsRNA-binding protein TARBP2 (TAR (HIV) RNA-binding protein 2) and the endoribonuclease DICER1 and processed by endonucleolytic cleavage into an approximately 18- to 24-nt-long miRNA/ miRNA* duplex. One strand of the miRNA/miRNA* duplex, usually the one with the lower 5′-end Watson-Crick base-pairing stability in the duplex, is then selected as the so-called “guide” (mature miRNA) strand and incorporated into a bigger protein complex, the miRNA-induced silencing complex (miRISC).

The pre-miRNA is subsequently exported from the nucleus into the cytoplasm by EXPORTIN-5 (XPO5, also known as EXP5) in a complex with RAN-GTP via the nuclear pore complex. In the cytoplasm, the pre-miRNA is bound by the dsRNA-binding protein TARBP2 (TAR (HIV) RNA-binding protein 2) and the endoribonuclease DICER1 and processed by endonucleolytic cleavage into an approximately 18- to 24-nt-long miRNA/ miRNA* duplex. One strand of the miRNA/miRNA* duplex, usually the one with the lower 5′-end Watson-Crick base-pairing stability in the duplex, is then selected as the so-called “guide” (mature miRNA) strand and incorporated into a bigger protein complex, the miRNA-induced silencing complex (miRISC).

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Sox2 : biology and role in development and disease by Hisato Kondoh, Robin Lovell-Badge


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