By Icon Health Publications
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Extra info for Sleep Deprivation - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
The research plan is conducted within the framework of three funded studies to use PET to investigate 1) serotonin-dopamine interactions in schizophrenia; 2) cholinergic modulation of monoamine function in Alzheimer's Disease; and 3) the effects of sleep deprivation and antidepressant treatment on cerebral glucose metabolism in geriatric depression. These studies are designed to relate alterations in monoamine responsiveness to subsequent therapeutic response. The long term goal of the candidate's research is to understand the neurobiologic substrates of treatment resistance in neurodegenerative disorders and to use the genetic, polysomnographic and imaging data to predict the course of pharmacotherapy.
Specifically, this project aims to: o Assess EMT-P performance deficits on standard cognitive and psychomotor tasks known to be sensitive to fatigue from partial sleep deprivation as well as low blood alcohol concentration (BAC), or alcohol hangover. o Validate the sensitivity of a rescue skill-specific programmable instrumented manikin-simulator with assessment protocols known to be sensitive to fatigue and hangover, and determine the extent to which the simulation can detect areas of task-relevant impairment among EMT-Ps when they are fatigued toward the end of typically long work shifts of 24 hours, and when they are coming onto a shift following moderate alcohol use that produces hangover symptoms 6 or more hours later.
These studies will help define the role of this newly identified neurotransmitter system in relation to motor behavior, the sleep wake cycle and in human disease. ; Assistant Professor; Neurology; Johns Hopkins University 3400 N Charles St Baltimore, Md 21218 Timing: Fiscal Year 2003; Project Start 01-JUN-2003; Project End 31-MAY-2005 Summary: (provided by applicant): Restless Legs Syndrome (RLS) is a common sensorymotor disorders whose symptoms predominant at night and often lead to significant sleep loss and changes in one's quality of life.
Sleep Deprivation - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References by Icon Health Publications