By Robert B. Livingston, Stephen K. Carter (auth.)
The medical trials software of anti-tumor medicines used to be begun by means of the nationwide melanoma Institute in 1955. some time past 15 years, this nationwide community has gathered a wide physique of knowledge on all the famous anti-tumor medicinal drugs in addition to upon new, experimentally promising brokers. whereas crucial of those experiences were released, there has remained a wealth of knowledge now not commonly to be had to the clinical neighborhood. Drs. Carter and Livingston haven't purely succeeded in organ~z~ng this massive corpus, they've got furthermore analyzed and interpreted the medical info in a fashion that may be hugely worthwhile for years yet to come. From a perusal of this quantity it turns into obvious that a few medicinal drugs are extra energetic opposed to definite tumors than have been learned; that the proof for the task of sure medicinal drugs opposed to particular tumors is usually tenuous; unusually, that a few hugely lively brokers have by no means been attempted opposed to a number of the quite universal tumors. Their huge paintings has supplied not just entry to the demanding info, it has additionally proven the necessity for learn to fill in vital gaps in our wisdom. The authors and the IFI/Plenum Press are to be congratulated for this beneficial and demanding paintings. C. Gordon Zubrod, M. D. clinical Director for Chemotherapy nationwide melanoma Institute nationwide Institutes of wellbeing and fitness Bethesda, Maryland v Acknowledgment The authors desire to thank Dr. C. Gordon Zubrod and Dr.
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3 "excellent" responses, 1 in HN 2resistant patient. " 5 n-< 1 (0 CR) o 11 1 7 16 8 11 24 (2 CR) 1 (0 CR) 1 4 52 48 II Pts Responding 63 89 II Pts Evaluated 52 Ref II Total. ALL-AUL 11%. (1) 150-200 mg/m /day, IV or subcutaneously x 7-14 days. Then daily PO maintenance. (2) 50-150 mg/m 2 /day, IV (for poor marrow reserve) as tolerated, followed by daily PO maintenance. 2 4 mg/kg/day, IV or PO, often IV x 14, then PO as tolerated. All received concomitant prednisone or halotestin. 3 mg/kg/day x 5-35 days, IV "loading" followed by PO maintenance.
Ten responses >4 mo duration. ) 43 6 17 12 62 14 8 34 40 41 59 65 5 3 9 6 16 31 II Pts Responding II Pts Evaluated Ref II 69 Response % British study. 4 mg/kg x 1, IV (unmaintained) - (HN2)' 2 CR; cross-over comparison study with HN 2 , which ~ 2 CR, 7 PR of 12. 5/9 HN 2-resistant patients had CR on CTX as 2nd therapy; 0/2 CTX-resistant patients had response to HN2 as 2nd therapy. 8 mo. 2 mg/kg/day, PO as tolerated (CTX) -- vs Vinblastine. All responses PRo Vinblastine ~ 9 CR, 11 PR of. 23. Varied (?
10 mg/kg/wk, PO, to response or limiting toxicity. ALGB study. All children previously treated. 2 mg/kg/day, PO, to response or limiting toxicity. ALGB study. All children previously treated. Daily dose less than that in other studies. 5 mg/kg/day PO maintenance. 5 mg/kg/day, PO. (50% of patients received "steroids" concomitantly). Steroid administration did not influence response rate (all patients were unresponsive to steroids, 6 MP, and MTX). No effect on CNS leukemia. 10/44 = 23% had Ml marrows.
Single Agents in Cancer Chemotherapy by Robert B. Livingston, Stephen K. Carter (auth.)