By Robert J. Alpern, Michael J. Caplan, Orson W. Moe
A vintage nephrology reference for over 25 years, Seldin & Giebisch's The Kidney, is the stated authority on renal body structure and pathophysiology. during this fifth variation, such new and robust disciplines as genetics and cellphone biology were deployed to deepen and widen extra the explanatory framework. not just have prior chapters been greatly up to date, yet new chapters were further to incorporate extra disciplines. person chapters, for instance, now offer distinctive therapy of the importance of cilia; the function of stem cells is now given designated attention. ultimately, there was an important growth of the portion of pathophysiology, incorporating the more recent findings of phone biology and genetics. for those who study the improvement of standard renal functionality or the mechanisms underlying renal disorder, Seldin & Giebisch's The Kidney is your no 1 resource for info. deals the main accomplished assurance out there of fluid and electrolyte legislation and dysregulation in eighty five thoroughly revised chapters and 10 new chapters.Includes 4sections, sixty two chapters, dedicated to law and problems of acid-base homeostasis, and epithelial and nonepithelial delivery legislation. contains foreword via Donald Seldin and Gerhard Giebisch, international popular names in nephrology and editors of the former 3 editions. Read more...
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In both cases, the provision of a flat, two-dimensional surface may provide spatial signals that normally would be generated by the cells themselves in vivo. In this regard, three-dimensional culture of cells in collagen gels, where a polarized cyst develops over 7 to 10 days (c), may more accurately represent the in vivo environment. In (d), an MDCK cell cyst is fluorescently labeled with antibodies to β-catenin to highlight the basolateral surface. Reprinted with permission from ref. 5). 177,178 As with permeable supports, the idea behind 3D cultures is that placing the epithelial cell in an environment in which it is surrounded by extracellular matrix similar to that of the interstitium more closely resembles the in vivo environment.
It is unclear how intracellular signaling events can cause laminin assembly. 191,192 Many of the components of the polarity complexes were initially identified in mutant screens in Caenorhabditis elegans and Drosophila melanogaster, but homologs that function in an essentially identical manner have also been identified in mammals. 8). A second apical complex is the Crumbs complex, containing in mammals the transmembrane protein Crumbs (Crb3 in the kidney) associated with Lin-7 (PALS1), and PALS1-associated tight junction protein (PATJ).
151 In the kidney such structures have not been reported. 145À149 A variety of kinases including, notably, focal adhesion kinase (FAK) and members of the src family of tyrosine kinases, associate with integrin adhesion complexes and are activated by binding to the extracellular matrix. Subsequent signals then activate downstream serine/threonine kinases, such as integrinlinked kinase (ILK), and MAP kinases, such as ERK, to regulate a diverse range of processes including proliferation, migration, and apoptosis.
Seldin and Giebisch's the kidney : physiology & pathophysiology by Robert J. Alpern, Michael J. Caplan, Orson W. Moe