By Mohammad Resa Nowrousian
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Extra info for Recombinant Human Erythropoietin (rhEPO) in Clinical Oncology: Scientific and Clinical Aspects of Anemia in Cancer, 2nd Edition
2003). Some of the receptors of the TNF receptor superfamily are decoy receptors able to compete with signaling receptors for ligand binding, thereby inhibiting their function. Examples of decoy receptors are given by DcR1 and DcR2 (also known as TRAIL-R3 and TRAIL-R4), competing with TRAILR1 and TRAIL-R2, respectively, for binding of TRAIL and DcR3 (sFas) competing with Fas for binding of FasL (Ashkenazi 2002). The physiologic role of these receptors is still unclear, but it has been suggested that they could protect some normal cells by their cytotoxic ligands.
Studies on GATA-1−/− embryonic stem cells induced in vitro to erythroid maturation showed that these cells failed to mature beyond the proerythroblast stage and undergo rapid apoptosis, thus suggesting an essential role for GATA-1 in erythroid survival, in addition to erythroid maturation (Weiss et al. 1994). Proerythroblast-like cells derived from GATA-1 knockdown ES cells have the ability to proliferate vigorously, but a GATA-1 level of 5% cannot sustain the gene expression required for maturation of proerythroblasts (Suwabe et al.
The activation of a death receptor by its ligand leads to the recruitment at the level of the receptor of a death adaptor, which in turn determines the rapid assembly of a death-inducing signaling complex (abbreviated as DISC), with consequent activation of the apoptosis-initiating caspases 8 and 10. Caspase-10 is an initiator caspase found in primates but not in rodents. The role of this caspase in initiating the apoptotic process is supported by two observations: a) lymphocytes from ALPS II patients bearing caspase-10 mutation are resistant to TRAIL-mediated killing (Wang et al.
Recombinant Human Erythropoietin (rhEPO) in Clinical Oncology: Scientific and Clinical Aspects of Anemia in Cancer, 2nd Edition by Mohammad Resa Nowrousian