By David M. Leitner, John E. Straub
Computational modeling promises a wealth of perception into how strength circulate in proteins mediates protein functionality. Computational tools may also tackle primary questions on the topic of molecular signaling and effort circulate in proteins. Proteins: strength, warmth and sign movement presents cutting-edge computational suggestions for learning strength redistribution, signaling, and warmth shipping in proteins and different molecular machines.
The first of 4 sections of the e-book handle the delivery of strength in molecular cars, which function through a mixture of chemically pushed large-scale conformational adjustments and cost delivery. targeting vibrational strength stream in proteins and nanostructures, the subsequent sections talk about methods in line with molecular dynamics simulations and harmonic research. via exploring the circulate of unfastened strength in proteins, the final part examines the conformational adjustments curious about allosteric transitions and the position of coupled protein–solvent dynamics in conformational adjustments. It additionally provides computational techniques constructed to find pathways among protein structures.
The built-in presentation of this finished, up to date quantity emphasizes the interrelations among disparate computational techniques that experience contributed to our knowing of power move in proteins and its position in protein functionality. by means of defining the leading edge of analysis during this region, the ebook delineates the present demanding situations and possibilities in constructing novel tools and purposes for the evolving learn of strength circulate in molecular machines and nanomaterials.
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Additional resources for Proteins: Energy, Heat and Signal Flow (Computation in Chemistry)
9. Boyer PD. 1997. The ATP synthase—A splendid molecular machine. Annual Review of Biochemistry 66: 717. 10. Brady ST. 1985. A novel brain ATPase with properties expected for the fast axonaltransport motor. Nature 317: 73. 11. Bustamante C, Keller D, Oster G. 2001. The physics of molecular motors. Accounts of Chemical Research 34: 412. 12. Carter NJ, Cross RA. 2005. Mechanics of the kinesin step. Nature 435: 308. 13. Clementi C, Nymeyer H, Onuchic JN. 2000. Topological and energetic factors: What determines the structural details of the transition state ensemble and “en-route” intermediates for protein folding?
Science 291: 667. 34. Kikkawa M, Okada Y, Hirokawa N. 2000. 15 angstrom resolution model of the monomeric kinesin motor, KIF1A. Cell 100: 241. 35. Kikkawa M, Sablin EP, Okada Y, Yajima H, Fletterick RJ, Hirokawa N. 2001. Switchbased mechanism of kinesin motors. Nature 411: 439. 36. Kolomeisky AB, Fisher ME. 2007. Molecular motors: A theorist’s perspective. Annual Review of Physical Chemistry 58: 675. 37. Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, et al. 1997. The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
2007. Mechanical control of the directional stepping dynamics of the kinesin motor. Proceedings of the National Academy of Sciences of USA 104: 17382. 31. Hyeon C, Thirumalai D. 2007. Mechanical unfolding of RNA: From hairpins to structures with internal multiloops. Biophysics Journal 92: 731. 32. Julicher F, Ajdari A, Prost J. 1997. Modeling molecular motors. Reviews of Modern Physics 69: 1269. 33. Kawaguchi K, Ishiwata S. 2001. Nucleotide-dependent single- to double-headed binding of kinesin.
Proteins: Energy, Heat and Signal Flow (Computation in Chemistry) by David M. Leitner, John E. Straub