Read e-book online Prostate Cancer New Horizons in Research and Treatment PDF

By Michael L. Cher, Kenneth V. Honn, Avraham Raz

ISBN-10: 030648143X

ISBN-13: 9780306481437

ISBN-10: 1402073526

ISBN-13: 9781402073526

In recent times the speed of analysis in prostate melanoma has elevated dramatically. artistic rules together with new and rising applied sciences have resulted in an explosion of discovery. some of these advances in prostate melanoma examine presage an period of latest therapy thoughts in accordance with an knowing of the mobile and molecular mechanisms of affliction. In growing this publication, we aimed to hide a extensive "bench to bedside" learn spectrum starting from: genetic, molecular and mobile analyses to epidemiological experiences, refinements in neighborhood remedy recommendations and new biologically established non-hormonal remedies for systemic affliction. Researchers and clinicians will locate during this publication a bunch of well timed and clinically proper chapters on prostate melanoma study and remedy.

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Regardless of the mechanism leading to androgen independence, downstream genes in the androgen pathway play a critical role in the development of hormone-refractory prostate cancer. Identification of differentially expressed genes One of the keys to understanding prostate growth and tumorigenesis is the identification of differentially expressed genes between normal and tumor prostate cells, and genes regulated by androgens. Much effort has been directed to identify such genes over the years. Prostate-specific antigen (PSA) is probably the best characterized androgen-regulated gene and a common diagnostic marker.

Honn and A. ), Prostate Cancer: New Horizons in Research and Treatment, 29–35. © 2002 Kluwer Academic Publishers. Printed in the Netherlands. 30 is AR amplification [4–6]. Increased levels of AR may allow tumor cells to survive and thrive in low androgen environments. Specific growth factors and cytokines, such as insulin-like growth factor-I (IGF-I) [7] and interleukin-6 (IL-6) [8] may also activate the AR in a ligand-independent manner. Coregulators can affect receptor transactivation depending upon the delicate balance between coactivator and corepressor expression levels [9,10].

V Honn and A. ), Prostate Cancer: New Horizons in Research and Treatment, 37–57. © 2002 Kluwer Academic Publishers. Printed in the Netherlands. 38 proposed in the two-hit theory [4,5], or have no effect on a cell’s phenotype if the retained allele has no mutations. The second type of regional deletion is hemizygous deletion, in which one chromosome is deleted but is not repaired, resulting in the loss of half genome for a locus. In addition to revealing a mutation, such hemizygous deletion can induce haploinsufficiency, in which loss of half genome results in insufficient gene product.

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Prostate Cancer New Horizons in Research and Treatment by Michael L. Cher, Kenneth V. Honn, Avraham Raz

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