Download e-book for iPad: Principles of Molecular Diagnostics and Personalized Cancer by Dongfeng Tan MD, Henry T. Lynch MD

By Dongfeng Tan MD, Henry T. Lynch MD

ISBN-10: 1451131976

ISBN-13: 9781451131970

Principles of Molecular Diagnostics and customized melanoma Medicine


The function of molecular genetics within the therapy of malignancy maintains to develop at an surprising price. Today’s subspecialized multidisciplinary method of oncology has integrated advances in unique molecular remedy, diagnosis, threat evaluate, and prevention—all dependent not less than partially on molecular diagnostics and imaging. within this state of the art source, readers will discover huge, complete views at the present tendencies in molecular analysis of melanoma and customized melanoma medication. Authoritative discussions proportion insights from famous specialists in melanoma study, medical trials, molecular diagnostics, customized remedy, bioinformatics, and federal laws. From the fundamental mechanisms of carcinogenesis to the main complicated molecular screening, staging, and remedy applied sciences, readers will realize transparent and simple discussions without delay appropriate to sufferer analysis and care.

Improve your figuring out of…

• the fundamental mechanisms of carcinogenesis—including fabric on cellphone proliferation, sign transduction pathways, melanoma stem cells, and the interplay among genetics and environmental factors. 
• the most up-tp-date molecular techniques—including  polymerase chain response (PCR) strategy, unmarried nucleotide polymorphisms, melanoma cytogenomics and epigenetics,  whole-genome exams, and subsequent- iteration sequencing.

• Molecular tests—including molecular screening, minimum residual sickness detection, circulating tumor phone assessments, molecular tumor staging, and molecular melanoma prognosis assessment.

• Imaging and screening technologies—including molecular imaging, genetic checks, biostatistics, and bioinformatics.

• The molecular foundation of therapy—including critical molecules as certain therapy ambitions, quite genes/DNA, RNA, micro RNAs, proteins/antibodies, and nanoparticles.

• Molecular diagnostics – including up to date molecular diagnostic methods to universal malignancies and position of pathology in specified melanoma management.

• special treatment  – together with custom-made medication and designated treatment for quite often happening malignancies— plus insights on new ways to specific drug discovery and the way forward for molecular oncology!

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Structure of mammalian AMPK and its regulation by ADP. Nature. 2011;472:230-233. 47. Steinberg GR, Kemp BE. AMPK in health and disease. Physiol Rev. 2009;89:1025-1078. 48. Pelicano H, Martin DS, Xu RH, Huang P. Glycolysis inhibition for anticancer treatment. Oncogene. 2006;25:4633-4646. 49. Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer. 1972;26:239-257. 50. Stennicke HR, Salvesen GS. Properties of the caspases.

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2011;39:466-471. 20. Garcia-Echeverria C. Blocking the mTOR pathway: a drug discovery perspective. Biochem Soc Trans. 2011;39:451-455. (c) 2015 Wolters Kluwer. All Rights Reserved. Chapter 21. Huang J, Manning BD. The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem J. 2008;412: 179-190. 22. Alessi DR, Pearce LR, Garcia-Martinez JM. New insights into mTOR signaling: mTORC2 and beyond. Sci Signal. 2009;2:pe27. 23. Bracho-Valdes I, Moreno-Alvarez P, Valencia-Martinez I, RoblesMolina E, Chavez-Vargas L, Vazquez-Prado J.

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Principles of Molecular Diagnostics and Personalized Cancer Medicine by Dongfeng Tan MD, Henry T. Lynch MD


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