New PDF release: Potassium Ion Channels Molecular Structure, Function, and

By Yoshihisa Kurachi, Lily Yeh Jan, Michel Lazdunski

ISBN-10: 0121533468

ISBN-13: 9780121533465

This ebook is the 1st to target potassium ion channels and covers the hot outstanding growth made in learn on those proteins. Many illnesses are brought on by the abnormalities of potassium ion channels. They contain diabetes mellitus, life-threatening hereditary cardiac arrhythmia, epilepsy, neural degeneration, and renal high blood pressure. Written by way of best scientists within the box, this quantity bargains readers a entire replace of this box within the realizing of the genes, molecular constitution, functionality and ailments of potassium ion channels.

Key Features
* the 1st complete quantity on potassium ion channels in all elements of genes, molecular constitution, functionality, and diseases
* thoroughly updated information
* Written through prime scientists within the box

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Extra info for Potassium Ion Channels Molecular Structure, Function, and Diseases

Example text

Gating of Shaker K+ channels. 2. The components of gating currents and a model of channel activation. Biophys. J. 66, 10111021. , Pardo, L. , and Pongs, 0. (1993). Ether-a-go-go encodes a voltage-gated channel permeable to Kf and CaZ+and modulated by CAMP. Nahire 365,445-448. , and Bezanilla, F. (1997). Characterizing voltage-dependent conformational changes in the Shaker K’ channel with fluorescence. Neuron 19, 1127-1140. Chandy, K. , and Gutman, G. A. (1995). Voltage-gated potassium channel genes.

Salkoff. , and Jegla. T. (1995). Surfing the DNA databases for K' channels nets yet more diversity. Neuron 15, 489-492. Sanguinetti, M. , Curran, M. , Zou, A.. , Spector, P. , Atkinson, D. , and Keating, M. T. (1996). Coassembly of KvLQTl and minK(1sK) proteins to form cardiac IKS potassium channel. Nature 384, 80-83. Sanguinetti. M. C.. , Curran. M. E.. and Keating, M. T. (1995). A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel.

C.. , and Barhanin, J . (1997). Properties of KvLQTl K’ channel mutations in Romano-Ward and Jervell and LangeNielsen inherited cardiac arrhythmias. EMBO J. 16, 5472-5479. Coburn. C. M.. and Bargniann, C. 1. (1996). A putative cyclic nucleotide-gated channal is required for sensory development and function in C. elegans. Neuron 17, 695-706. Curran. , Splawski, I.. Timothy, K. W.. Vincent, G. , Green, E. , and Keating. M. T. (19%). A molecular basis for cardiac arrhythmia: H E R G mutations cause long QT syndrome.

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Potassium Ion Channels Molecular Structure, Function, and Diseases by Yoshihisa Kurachi, Lily Yeh Jan, Michel Lazdunski

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