Download e-book for iPad: Phosphoinositide 3-kinase in Health and Disease: Volume 1 by Christian Rommel, Bart Vanhaesebroeck, Peter K. Vogt

By Christian Rommel, Bart Vanhaesebroeck, Peter K. Vogt

ISBN-10: 3642136621

ISBN-13: 9783642136627

ISBN-10: 364213663X

ISBN-13: 9783642136634

From humble beginnings over 25 years in the past as a lipid kinase job linked to definite oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the vanguard of drug improvement in melanoma, immunity and thrombosis, with the 1st medical trials of PI3K pathway inhibitors now in growth. the following we supply a quick evaluation of a few key discoveries within the PI3K region and their influence, and contain techniques at the present nation of the sector, and the place it might probably cross from the following

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Additional info for Phosphoinositide 3-kinase in Health and Disease: Volume 1 (Current Topics in Microbiology and Immunology, Volume 346)

Sample text

4 PKB in Adipocyte Differentiation . . . . . . . . . . . . . . . . . . . . . . . . . . 5 PKB in Glucose Homeostasis . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 PKB in Tumor Formation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 46 4 Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 References . .

39 3 The Role of PKB in Physiological and Pathological Conditions . . . . . . . . . . . . . 1 Effects of Knocking Out Individual PKB Isoforms in Mice . . . . . . . . . . . . . 2 PKB in Embryonic Development . . . . . . . . . . . . . . . . . . . . . . . . . . 3 PKB in Thymocyte Development . . . . . . . . . . . . . . . . . . . . . . . . . . 4 PKB in Adipocyte Differentiation . . . . . . . .

1999). Although PDK1 was shown to be itself oncogenic when expressed in mammary epithelial cells (Zeng et al. 2002; Xie et al. 2003), there are, however, not many reports showing PDK1 alterations in human disease. For example, increased PDK1 expression has been reported in invasive breast cancers, suggesting its importance in the metastatic process (Xie et al. 2006). Overexpression of PDK1 has been reported in 45% of patients with acute myeloid leukaemia, which is closely associated with hyperphosphorylation of PKC isoforms (Pearn et al.

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Phosphoinositide 3-kinase in Health and Disease: Volume 1 (Current Topics in Microbiology and Immunology, Volume 346) by Christian Rommel, Bart Vanhaesebroeck, Peter K. Vogt


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