Download PDF by Milo Gibaldi, Donald Perrier: Pharmacokinetics, Second Edition (Drugs and the

By Milo Gibaldi, Donald Perrier

ISBN-10: 0824710428

ISBN-13: 9780824710422

ISBN-10: 1420089145

ISBN-13: 9781420089141

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8. T. Walle, T. C. Fagan, E. C. Conradi, U. K. Walle, and T. E. Gaffney. Presystemic and systemic glucuronidation of propranolol. Glin. Pharmacol. Ther. 26: 167 (1979). 1 / One-Compartment Model 9. 43 C. G. Regardh, L. Elk, and K. J. Hoffmann. Plasma levels and l3-blocking effect of a-hydroxymetoprolol-metabolite of metoprolol-in the dog. J. Pharmacokinet. Biopharm. 7:471 (1979) . 10. D. H. Huffman, D. W. Shoeman, and D. L. Azarnoff. Correlation of the plasma elimination of antipyrine and the appearance of 4hydroxyantipyrine in the urine of man.

1. 67) Upon rearrangement it can be shown that C -C ss C (1. -3-0-3 (1. 69) A semilogarithmic plot of (C s s - C) ICss versus time yields a straight line with a slope of -K/2. 303. The elimination rate constant may be estimated directly from the slope. The half-life may be estimated either directly from the semilogarithmic plot or from K by rearranging Eq. 70) The elimination rate constant may also be determined using the declining drug concentration in plasma versus time data collected after stopping the infusion.

B: 1 (1980). 2. T. J. Mellinger and J. G. Bohorfousch. Pathways and tissue distribution of dipyridamole. Arch. Int. Pharmacodyn. 156:380 (1965) . 3. A. Goldstein. Biostatistics-An Introductory Text. Macmillan, New York, 1964. 4. G. R. Wilkinson and A. H. Beckett. Absorption, metabolism and excretion of the ephedrines in man: I. The influence of urinary pH and urine volume output. J. Pharmacol. Exp. Ther. 162:139 (1968) . 5. J. A. Taylor. Pharmacokinetics and biotransformation of chlorpropamide in man.

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Pharmacokinetics, Second Edition (Drugs and the Pharmaceutical Sciences: a Series of Textbooks and Monographs) by Milo Gibaldi, Donald Perrier


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