By H. Parmar, R. H. Phillips, S. L. Lightman (auth.), Prof. Dr. K. Höffken (eds.)
This moment of 2 volumes offers the cutting-edge in somatostatin analogues and bombesin antagonists in neoplastic ailments. It offers an in depth description of mechanisms of motion and the current medical relevance of those new ways in melanoma therapy. every one bankruptcy has been ready via a professional lively within the respective experimental and/or medical box in order that the reader is guaranteed of acquiring the newest details at the subject.
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Additional info for Peptides in Oncology II: Somatostatin Analogues and Bombesin Antagonists
With a significant reduction of soft tissue swelling, moderate improvement of arthropathy has been observed (Harris 1991). Furthermore, sleep apnea can be improved, and beneficial effects on cardiac function can be noted in acromegaly patients after octreotide therapy. For example, a few weeks of treatment with octreotide has been observed to lead to recovery of normal physical activity, the previously used therapy for heart failure could be reduced, and the heart size normalized, as documented by X-ray (Harris 1991).
J Clin Endocrinol Metab 68: 844~ 850 Reubi JC, Heitz PU, Landolt AM (1987) Visualization of somatostatin receptors and correlation with immunoreactive growth hormone and prolactin in human pituitary adenomas: evidence for different tumor subclasses. J Clin Endocrinol Metab 65: 65 ~ 73 Ross DA, Wilson CB (1988) Results of transsphenoidal microsurgery for growth hormone secreting pituitary adenomas in a series of 214 patients. J Neurosurg 68:854~867 Sano T, Asa SL, Kovacs K (1991) Growth hormone releasing hormone producing tumours: clinical, biochemical and morphological manifestations.
1991). In conclusion, although pituitary scintigraphy seems to be a valid tool for screening patients, regardless of whether they have NFPAs that are somatostatin receptor positive or ones that are negative, octreotide treatment should be carefully monitored after a possible increase in tumor mass. Whether presurgical octreotide treatment may facilitate a more radical surgery of NFPA as it seems to be the case in acromegaly is an open question. Somatostatin Analogues in Pituitary Adenomas 39 Cushing's Disease Somatostatin has been shown to inhibit ACTH secretion from the mouse tumour cell line AtT20 and is effective in suppressing the ACTH release stimulated by ACTH-releasing hormone (CRH) from rat anterior pituitary cells in the absence of cortisol (Stalla et al.
Peptides in Oncology II: Somatostatin Analogues and Bombesin Antagonists by H. Parmar, R. H. Phillips, S. L. Lightman (auth.), Prof. Dr. K. Höffken (eds.)