Download PDF by A. Ian Smith: Peptidases and Neuropeptide Processing

By A. Ian Smith

ISBN-10: 0080536425

ISBN-13: 9780080536422

ISBN-10: 0121852938

ISBN-13: 9780121852931

The volumes during this sequence comprise modern concepts major to a selected department of neuroscience. they're a useful reduction to the coed in addition to the skilled researcher not just in constructing protocols in neuroscience yet in disciplines the place learn is changing into heavily relating to neuroscience. every one quantity of equipment in Neurosciences includes an index, and every bankruptcy contains references. Dr. Conn turned Editor-in-Chief of the sequence starting with quantity 15, so each one next quantity will be guest-edited via a professional in that categorical box. This extra strengthens the intensity of assurance in equipment in Neurosciences for college kids and researchers alike. finished protocols integrated for:* Enzymes occupied with the activation of bioactive peptidases and proteins* Prohormone/neuropeptide processing pathways* Enzymes curious about peptide metabolism* Posttranslational processing enzymes

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A. M. Braks, K. W. C. Guldemond, M. C. H. M. van Riel, A. J. M. Coenen, and G. J. M. Martens, FEBS Lett. 305, 45 (1992). S. Benjannet, N. Rondeau, L. Paquet, A. Boudreault, C. Lazure, M. Chr6tien, and N. G. Seidah, Biochem. J. 294, 735 (1993). A. Boudreault, N. Rondeau, N. G. Seidah, M. Chr6tien, and C. Lazure, J. Biol. Chem. (submitted for publication) (1994). M. Marcinkiewicz, R. Day, N. G. Seidah, and M. Chr6tien, Proc. Natl. Acad. Sci. A. 90, 4922 (1993). -H. Sch~ifer and Robert Day Introduction Great progress has been made in the molecular identification of the enzymes involved in posttranslational processing of neuropeptides.

Excess emulsion is allowed to drip back into the emulsion and the bottom edge of the slide is touched by a paper towel. Slides are placed upright into a scintillation vial box to dry completely (several hours to overnight). Slides are then transferred to black slide boxes that contain desiccant capsules and sealed with electrical tape, wrapped in foil, and stored at 4~ for various exposure times, using the X-ray exposure as a guideline. Developing All photographic solutions are cooled in the dark room to 14~ Slide boxes are allowed to warm to room temperature to avoid the formation of condensation.

Although coexpression of precursor and substrate in different cell lines may indicate the ability of a convertase to cleave a given precursor, it is by no means proof that such processing occurs in vivo in every tissue where the substrate is expressed. A typical example is human prorenin, which can be efficiently processed by PC 1; however, this convertase does not colocalize with renin within the kidney juxtaglomerular cells. Therefore, before accepting the role of a given convertase in the processing of a precursor, careful colocalization studies should complement the cleavage selectivity data obtained from cellular coexpression experiments.

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Peptidases and Neuropeptide Processing by A. Ian Smith

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