New PDF release: Pediatric Gastrointestinal and Liver Disease:

By Robert Wyllie, Jeffrey S. Hyams

ISBN-10: 0721639240

ISBN-13: 9780721639246

This is every little thing you want to deal with the whole diversity of pediatric GI and liver diseases...in a handy, concise unmarried resource. Drs Wyllie and Hyams - in addition to greater than eighty specialists within the box - convey you a clinically centred reference that includes a uniform bankruptcy association and a wealth of illustrations and diagrams to make tips effortless to either locate and apply.Offers an advantage site that includes 500 case-study, self-assessment questions - with solutions - besides colour medical photographs, that can assist you try your knowledge.Presents plentiful explanatory diagrams which make clear complicated concepts.Features a signs-oriented part, making analysis more uncomplicated and guiding you to targeted disease-specific sections.Integrates pathophysiology, medical facts, and patient-oriented info throughout.Presents 8 new chapters for multiplied assurance at the pediatric liver.Offers a brand new appendix of pediatric drug dosages, to help you in prescribing "off label."With over eighty extra contributing specialists.

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Extra info for Pediatric Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management (3rd Edition)

Example text

Bile acid-induced diarrhea. In: Lebenthal E, Duffey M, eds. Textbook of Secretory Diarrhea. New York, NY: Raven Press; 1990:281–290. 20. Setchell KD, Suchy FJ, Welsh MB, et al. Delta 4-3-oxosteroid 5 beta-reductase deficiency described in identical twins with neonatal hepatitis. A new inborn error in bile acid synthesis. J Clin Invest 1988; 82:2148–2157. 21. Balistreri WF. Inborn errors of bile acid biosynthesis and transport-novel forms of metabolic liver disease. Gastroenterol Clin North Am 1999; 28:145–172.

The basolateral membranes of hepatocytes express the bile salt (BS) transporters Na+-taurocholate cotransporting polypeptide (NTCP) and organic anion transporting polypeptides (OATP). Bile salts are then transported into the canalicular lumen by the bile salt export pump (BSEP) and multidrug resistance protein 2 (MRP2). In addition, phospholipids are transported across the canalicular membrane by the multi-drug resistant type 3 protein (MDR3) while aminophospholipids are transported by the familial intrahepatic cholestasis type 1 (FIC1) transporter.

Clin Liver Dis 2000; 4:831–848. 5. Hofmann AF. The continuing importance of bile acids in liver and intestinal disease. Arch Intern Med 1999; 159:2647–2658. 6. Huijghebaert SM, Hofmann AF. Pancreatic carboxypeptidase hydrolysis of bile acid-amino acid conjugates: selective resistance of glycine and taurine amidates. Gastroenterology 1986; 90:306–315. 7. Bahar RJ, Stolz A. Bile acid transport. Gastroenterol Clin North Am 1999; 28:27–58. 16. Kaplan GS, Bhutani VK, Shaffer TH, et al. Gallbladder mechanics in newborn piglets.

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Pediatric Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management (3rd Edition) by Robert Wyllie, Jeffrey S. Hyams


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