Luis Sierrasesúmaga-Ariznabarreta, Moira Garraus (auth.),'s Pediatric Bone Sarcomas: Epiphysiolysis before excision PDF

By Luis Sierrasesúmaga-Ariznabarreta, Moira Garraus (auth.), Mikel San-Julian, José Cañadell (eds.)

ISBN-10: 1848821298

ISBN-13: 9781848821293

ISBN-10: 1848821301

ISBN-13: 9781848821309

Pediatric Bone Sarcomas: Epiphysiolysis ahead of excision addresses malignant bone tumours through focusing upon physeal distraction (epiphysiolysis) prior to excision. this system has lengthy been utilized by the authors of this booklet in protecting the joint in metaphyseal bone tumours in young children. they're consequently now sharing their wisdom and event with all these within the box of orthopedic surgery.

In the final 30 years, the end result for sufferers tormented by malignant bone tumours has stronger dramatically. higher wisdom of the disorder, better imaging equipment, new surgical innovations and especially the appearance of chemotherapy have led to expanding good fortune during this box.

Preserving the lifetime of those sufferers 30 years in the past was once the one target of physicians. Now, survival charges have elevated and the hot demanding situations posed to the health professional are on holding the limb and its functionality, when averting problems. 30 years in the past joint protection with regards to the bone tumour was once unprecedented. extra lately, this can be a wish and attainable consequence universal to all people who treats those patients.

Targeted essentially in the direction of orthopedic surgeons and pediatric oncologists this publication may also be of curiosity to all these within the fields of orthopedics, oncology, pediatrics and surgery.

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J Surg Oncol. 2008;97:259–266. 13. Wunder JS, Gokgoz N, Parkes R, et al. TP53 mutations and outcome in osteosarcoma: a prospective, multicenter study. J Clin Oncol. 2005;23:1483–1490. 14. Belchis DA, Gocke CD, Geradts J. Alterations in the rb, p16, and cyclin d1 cell cycle control pathway in osteosarcomas. Pediat Pathol Mol Med. 2000;19:377–389. 15. Yamaguchi T, Toguchida J, Yamamuro T, et al. Allelotype analysis in osteosarcomas: frequent allele loss on 3q, 13q, 17p, and 18q. Cancer Res. 1992;52:2419–2423.

49,54 The TET family also includes TAFII68 (or TAF15)55,56 and FUS (or TLS),57 both of which share similar structural domains with EWS and have been found to form gene fusions with non-ETS transcription factors, giving rise to non-Ewing sarcomas such as myxoid liposarcomas,58 myxoid chondrosarcomas59 and desmoplastic small round-cell tumours,60 with different histopathological features. 55,54 In addition, TET proteins interact with splicing proteins. 65 Most studies have focused on the function of EWS as a transcription factor.

Foukas AF, Deshmukh NS, Grimer RJ, Mangham DC, Mangos EG, Taylor S. Stage-IIB osteosarcomas around the knee A study of MMP-9 in surviving tumor cells. J Bone Joint Surg Br. 2002;84:706–711. 6. Kido A, Tsutsumi M, Iki K, et al. Overexpression of matrix metalloproteinase (MMP)-9 correlates with metastatic potency of spontaneous and 4-hydroxyaminoquinoline 1-oxide (4-HAQO)-induced transplantable osteosarcomas in rats. Cancer Lett. 1999;137:209–216. 7. Pakos EE, Ioannidis JP. The association of P-glycoprotein with response to chemotherapy and clinical outcome in patients with osteosarcoma A meta-analysis.

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Pediatric Bone Sarcomas: Epiphysiolysis before excision by Luis Sierrasesúmaga-Ariznabarreta, Moira Garraus (auth.), Mikel San-Julian, José Cañadell (eds.)


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