By Peter A. Calabresi, Laura J. Balcer, Elliot M. Frohman
Optical coherence tomography [OCT] presents tissue morphology imagery at a lot larger answer than different imaging modalities resembling MRI or ultrasound, and the machines are relatively more affordable. it truly is a simple strategy to practice; is non-ionizing, and accordingly secure. those advantages are using a speedy transformation of OCT, from its relevant software as a learn device, into an extension of the 'neurological exam' in regimen place of work perform. initially utilized in assessing the severity of tissue harm and analysis of a number of sclerosis and numerous neuro-ophthalmic stipulations, OCT is more and more utilized in different neurological issues corresponding to Parkinson's disorder, ALS, and Alzheimer's illness. This e-book is the 1st finished evaluate of using OCT in neurological illnesses. The insurance features a description of the process and its usage in a number of neurologic stipulations. crucial interpreting for neurologists, neuro-ophthalmologists, and neuroradiologists short of an introductory account of the scientific functions of OCT.
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Additional resources for Optical Coherence Tomography in Neurologic Diseases
However, the optic disc margin is not perfectly circular, so a peripapillary scan path is not equidistant from the disc margin at all points, which is a potential source of error in these measurements. 4 mm circular scan in persons with larger optic discs . OCT software facilitates RNFL comparisons between the two eyes, where even subtle asymmetries can be detected. 93) Thickness [µm] TS 144 (137) 180 120 60 TI 158 (145) NI 103 (107) 0 –180 NAS –135 –90 INF –45 0 TMP Position [°] 45 90 SUP 135 180 NAS Within Normal Limits Warning: Classification results valid for Caucasian eyes only.
The optic neuritis associated with neuromyelitis optica is more often bilateral. , unilateral symptoms), where changes in the visual ﬁeld can be identiﬁed on formal examination in the fellow eye; in the ONTT, 48% of patients had some abnormality detected in the fellow eye . There are also chronic and subclinical forms of optic neuritis. The chronic form, which should not be diagnosed without excluding compressive lesions on neuroimaging, can occur as the presenting symptom of multiple sclerosis  or develop later in the course of the disease .
4). The time taken for loss of macular volume (our modeling suggests that 99% of the loss takes place by approximately 11 months) seems to be longer than that of RNFL thickness, suggesting that perhaps thinning of deeper layers, such as thinning of the ganglion cell layer, or diﬀerent mechanisms, such as trans-synaptic retinal degeneration, are at play in the macula. 3 Asymmetric swelling of the RNFL in a patient with chronic relapsing inﬂammatory optic neuropathy (CRION). The images were taken ten days after the onset of bilateral eye pain, pain on eye movement, and development of bilateral reduced visual acuity and visual ﬁeld sensitivity.
Optical Coherence Tomography in Neurologic Diseases by Peter A. Calabresi, Laura J. Balcer, Elliot M. Frohman