Neurotransmitter Transporters: Investigative Methods by Heinz Bönisch, Harald H. Sitte PDF

By Heinz Bönisch, Harald H. Sitte

ISBN-10: 1493937634

ISBN-13: 9781493937639

The amount goals at supplying an outline of state-of-the-art equipment and protocols utilized in neuroscience and neurological learn. Neurotransmitter Transporters: Investigative equipment might be of curiosity to scientists, graduate scholars, and complex undergraduates who search an outline of tools and protocols during this box of neuroscience. it is going to even be of curiosity to physicians who're conducting imaging and postmortem experiences of neurotransmitter transporters within the human mind. Written for the preferred Neuromethods sequence, chapters comprise the type of element and key implementation suggestion that guarantees profitable leads to the laboratory.

Authoritative and functional, Neurotransmitter Transporters: Investigative tools goals to make sure winning ends up in the additional learn of this important field.

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Extra info for Neurotransmitter Transporters: Investigative Methods

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Phosphate-buffered saline (PBS) containing protease inhibitors (Roche Complete™). , BCA kit, Pierce/Thermo Scientific). 24-well plates. Whatman GF/B filters (1 mm diameter). 2 Slice Preparation from Animal Brain Tissue Krebs-HEPES buffer or KHensB buffer (see above for composition). Animal brain removed from either mouse or rat. McIlwain tissue chopper (Fig. 1) for the preparation of brain slices. , Gibco, Invitrogen Life Science, Bethesda, MD). Fetal bovine serum (FBS). 26 Thomas Steinkellner et al.

Stöber G, Nöthen MM, Pörzgen P, Brüss M, Bönisch H, Knapp M, Beckmann H, Propping P (1996) Systematic search for variation in the human norepinephrine transporter gene: identification of five naturally occurring missense mutations and study of association with major psychiatric disorders. Stöber G, Hebebrand J, Cichon S, Brüss M, Bönisch H, Lehmkuhl G, Poustka F, Schmidt M, Remschmidt H, Propping P, Nöthen MM (1999) Tourette syndrome and the norepinephrine transporter gene: results of a systematic mutation screening.

Singh SK, Piscitelli CL, Yamashita A et al (2008) A competitive inhibitor traps LeuT in an open-to-out conformation. Science 322:1655–1661 9. Singh SK, Yamashita A, Gouaux E (2007) Antidepressant binding site in a bacterial homologue of neurotransmitter transporters. Nature 448:952–956 10. Yamashita A, Singh SK, Kawate T et al (2005) Crystal structure of a bacterial homologue of Na+/Cl−-dependent neurotransmitter transporters. Nature 437:215–223 11. Forrest LR, Rudnick G (2009) The rocking bundle: a mechanism for ion-coupled solute flux by symmetrical transporters.

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Neurotransmitter Transporters: Investigative Methods by Heinz Bönisch, Harald H. Sitte

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