Download PDF by Nai-Kong V. Cheung, Susan L. Cohn: Neuroblastoma

By Nai-Kong V. Cheung, Susan L. Cohn

ISBN-10: 354040841X

ISBN-13: 9783540408413

Neuroblastoma is a clinical enigma. As a formative years neoplasm coming up from neural crest cells, it truly is characterised via various medical behaviors starting from spontaneous remission to swift tumor development and dying. even if medical final result could be anticipated to a wide volume by means of the degree of affliction and the age at prognosis, an in-depth figuring out of its clinico-pathological habit, now vastly aided by way of subtle molecular genetic profiling, will enhance diagnostic precision and refine risk-based treatments. entire overseas efforts have complicated our realizing of tumor biology and more advantageous the scientific administration of kids with neuroblastoma. This booklet stories our present realizing of the genes and organic pathways that give a contribution to neuroblastoma pathogenesis, sleek risk-based therapy techniques for those sufferers, and up to date advances in biologically established treatment. It offers a concise updated reference for practitioners, scholars, and researchers.

Show description

Read Online or Download Neuroblastoma PDF

Best oncology books

New PDF release: Vegetables, Whole Grains, and Their Derivatives in Cancer

Greens, entire Grains and their Derivatives in melanoma Prevention appears to be like intimately on the facts in regards to the results and mechanisms of motion of doubtless cancer-preventive elements and their assets from plant state. The booklet covers present wisdom on convinced meals and their materials in melanoma prevention, corresponding to cruciferous and eco-friendly leafy greens, nuts and seeds, complete grains, tomato lycopene and carotenoids, alliums and their sulphur and selenium materials, and capsaicinoids from chilli peppers.

Download e-book for kindle: Malignant Mesothelioma - A Medical Dictionary, Bibliography, by Icon Health Publications

This can be a 3-in-1 reference publication. It offers an entire scientific dictionary masking countless numbers of phrases and expressions in relation to malignant mesothelioma. It additionally provides broad lists of bibliographic citations. ultimately, it offers info to clients on tips to replace their wisdom utilizing quite a few net assets.

Read e-book online BRAF Targets in Melanoma: Biological Mechanisms, Resistance, PDF

​This quantity incorporates a number of writings from the leaders within the fields of Molecular Biology and cancer examine with the intention to start to inform the ever-expanding tale of the latest findings, discoveries, and power of BRAF-directed pursuits in cancer. fresh study has proven that BRAF inhibitors are powerful for a quick time period, yet there's little wish that this medicinal drugs as unmarried brokers will bring about sturdy gain in a majority of sufferers.

New PDF release: Biopsy Interpretation of Soft Tissue Tumors

Biopsy Interpretation of soppy Tissue Tumors is a realistic advisor and bench reference for surgical pathologists for the translation of sentimental tissue biopsies, together with open and percutaneous center needle biopsies. each one bankruptcy publications readers in a logical means, with the most important differential diagnostic good points of particular tumors targeted inside every one type, utilizing morphologic, immunohistochemical, ultrastructural, and genetic facts.

Additional resources for Neuroblastoma

Sample text

Med Pediatr Oncol 33:360– 361 Woods WG, Gao R, Shuster J et al. (2002) Screening of infants and mortality due to neuroblastoma. N Engl J Med 346: 1041–1046 Yamamoto K, Hayashi Y, Hanada R et al. (1995) Mass screening and age-specific incidence of neuroblastoma in Saitama Prefecture, Japan. J Clin Oncol 13:2033–2038 W. G. Woods Yamamoto K, Hanada R, Kikuchi A et al. (1998) Spontaneous regression of localized neuroblastoma detected by mass screening. J Clin Oncol 16:1265–1269 Yamamoto K, Ohta S, Ito E et al.

1 Introduction It a major tenet in cancer research that alterations in cellular genes lead to the malignant transformation of normal cells. Two major classes of cancer-related genes have been identified: (a) oncogenes, which contribute to cancer “dominantly” by positive modulation of cellular growth; and (b) tumor suppressor genes, which are thought to control normal cellular growth and differentiation and act in a “recessive” negative way, contributing to cancer through functional inactivation.

2001). 6 Conclusions There are two published studies that used classic genetic linkage methods to localize hereditary neuroblastoma predisposition genes. In a genome-wide search for linkage in seven pedigrees with at least two first-degree relatives affected with neuroblastoma, convincing evidence was discovered that a hereditary neuroblastoma predisposition gene (HNB1) is located on the distal short arm of chromosome 16 (16p12–13; Fig. 1) (Maris et al. 2002). 7 (Maris et al. 2003). Loss of heterozygosity has been observed in 13% of sporadic neuroblastomas, suggesting that somatic inactivation of a 16p tumor suppressor gene might contribute to neuroblastoma initiation or progression in at least a subset of nonfamilial cases (Furuta et al.

Download PDF sample

Neuroblastoma by Nai-Kong V. Cheung, Susan L. Cohn

by David

Rated 4.35 of 5 – based on 26 votes