By H. Georg Kuhn, Amelia J. Eisch
This accomplished quantity is the 1st to in particular goal constructing, grownup and diseased neural stem cells. It explores fresh advances within the knowing of neural stem mobilephone biology besides techniques that use those cells to take on neurological illnesses and mind getting older. Ten inclusive chapters speak about quite a lot of subject matters together with neurogenesis, neurodegeneration, demyelinating ailment, temper law, and spinal twine regeneration, between others.
Written through world-renowned scientists within the box, Neural Stem Cells in improvement, maturity and Disease offers state-of-the-art reports of curiosity to either proven neurogenesis researchers and readers with normal pursuits in frightened procedure technology. it truly is an authoritative addition to the Stem cellphone Biology and Regenerative medication series.
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Additional resources for Neural Stem Cells in Development, Adulthood and Disease
1 (a) Schematic diagram showing developmental stages of SVZ neurogenesis. RGLs (type B cells) in the SVZ, when activated, divide asymmetrically with one daughter cell differentiating into IPCs (type C cells). IPCs actively proliferate and generate neuroblasts (type A cells). Neuroblasts migrate through the rostral migratory stream (RMS) and then become mature interneurons and integrate into the local neuronal circuitry in the olfactory bulb. Cells at different stages of SVZ neurogenesis express stage-specific markers, and the process of neurogenesis is regulated by niche cells, including ependymal cells, astrocytes, and vascular endothelial cells.
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I. Ventricular zone cell proliferation. Cell and Tissue Research, 271, 341–50. Chojnacki, A. , Mak, G. , & Weiss, S. (2009). Identity crisis for adult periventricular neural stem cells: subventricular zone astrocytes, ependymal cells or both? Nature Review Neuroscience, 10, 153–63. , Biancotti, J. , Krueger, R. , & Sun, Y. E. (2008). CD133+ neural stem cells in the ependyma of mammalian postnatal forebrain. Proceedings of the National Academy of Sciences of the United States of America, 105, 1026–31.
Neural Stem Cells in Development, Adulthood and Disease by H. Georg Kuhn, Amelia J. Eisch