By Shamim Ahmad, Sandra Kirk
Molecular Mechanisms of Fanconi Anemia will supply examine scholars a platform for additional research, and act as a resource of data relating to experimental layout. Clinicians will find this identify beneficial for its accomplished description of Fanconi Anemia and knowledge at the most modern molecular theories underlying its reasons.
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Additional resources for Molecular Mechanisms of Fanconi Anemia (Medical Intelligence Unit)
Using a global immunoprecipitation method, Meetei et al identified 3 distinct multiprotein complexes associated with the Blooms protein, BLM. One of these ("BRAFT") contained topoisomerase Ill-alpha, replication protein A and the core complex FA proteins. ^^'^^ In summary, most of the FA genes have been cloned now and the elucidation of the FA nuclear complex model by Garcia-Higuera et al^i''^6'i29 j ^ ^ h^^n extraordinarily helpful in describing a unified vision of how mutations of these disparate proteins can lead to the same aberrant response to MMC.
97. de Winter JP, Waisfisz Q, Rooimans MA et al. T h e Fanconi anaemia group G gene F A N C G is identical with X R C C 9 . Nat Genet 1998; 20(3):281-283. 98. Kuang Y, Garcia-Higuera I, Moran A et al. Carboxy terminal region of the Fanconi anemia protein, F A N C G / X R C C 9 , is required for functional activity. Blood 2000; 96(5):1625-1632. 99. Futaki M , Watanabe S, Kajigaya S et al. Fanconi anemia protein, F A N C G , is a phosphoprotein and is upregulated with FANCA after TNF-alpha treatment.
Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of G S T P l . Nat Med 2001; 7(7):814-820, 55. Maciejewski JP, Selleri C, Sato T et al. Increased expression of Fas antigen on bone marrow CD34* cells of patients with aplastic anaemia. Br J Haematol 1995; 91:245-252. 56. Pang Q , Keeble W , Diaz J et al. Role of double-stranded RNA-dependent protein kinase in mediating hypersensitivity of Fanconi anemia complementation group C cells to interferon gamma, tumor necrosis factor-alpha, and double-stranded RNA.
Molecular Mechanisms of Fanconi Anemia (Medical Intelligence Unit) by Shamim Ahmad, Sandra Kirk