Molecular mechanisms in gastrointestinal cancer - download pdf or read online

By B. Mark, M.D. Evers, B. Mark Evers

ISBN-10: 0585408777

ISBN-13: 9780585408774

Univ. of Texas, Galveston. Discusses the capability function of the arachidonic acid/prostaglandin pathway in sure gastrointestinal cancers, and the position angiogenesis may well play in progress and metastasis of cancers. For researchers and practitioners in surgery.

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66. Sakai T, Kawakatsu H, Fujita M et al. An epitope localized in c-Src negative regulatory domain is a potential marker in early stage of colonic neoplasm. Lab Invest 1998; 87:219-225. 67. Lutz MP, Eber IBS, Flossmann-Kast BBM et al. Overexpression and activation of the tyrosine kinase Src in human pancreatic carcinoma. Biochem Biophys Res Commun 1998; 243:503-508. 68. Okada M, Nada S, Yamanashi Y et al. CSK: A protein-tyrosine kinase involved in regulation of Src family kinases. J Biol Chem 1991; 266:24249-24252.

Cell Signal 1997; 9:337-351. 82. Woodgett JR, Arruch J, Kyriakis J. The stress activated protein kinase pathway. Cancer Surv 1997; 27:127-138. 83. Mansour SJ, Matten WT, Hermann AS et al. Transformation of mammalian cells by constitutively active MAP kinase kinase. Science 1994; 265:966-970. 84. Robinson MJ, Cobb MH. Mitogen-activated protein kinase pathways. Curr Opin Cell Biol 1997; 9;180-186. 85. Gutkind JS. The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades.

Protein Tyrosine Kinases Protein tyrosine kinases (PTKs), as the name indicates, differ from other kinases in that they catalyze the phosphorylation of tyrosine residues as opposed to serine/threonine residues. 59,60 While some members of the Src family are ubiquitously expressed, others show tissue selective expression and function. For this discussion, we will refer primarily to the prototype tyrosine kinase, Src. An extensive review of all PTKs, even one of the Src family alone, is well beyond the scope of this section.

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Molecular mechanisms in gastrointestinal cancer by B. Mark, M.D. Evers, B. Mark Evers

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