Model Systems in Aging - download pdf or read online

By Thomas Nyström, Heinz D. Osiewacz

ISBN-10: 3540024905

ISBN-13: 9783540024903

ISBN-10: 3540370056

ISBN-13: 9783540370055

Aging is the revolutionary decline in organic features through the years. This decline objectives macromolecules, cells, tissues and, in this case, complete organisms. regardless of significant development within the improvement of testable speculation bearing on getting older in an evolutionary context, a unifying idea of the molecular/physiological mechanistic factors of getting older has now not been reached. in reality, is it now not transparent to what quantity getting older is a programmed or stochastic strategy.

This publication takes the reader from unicellular bacterial deterioration through senescence in yeast and worms to getting older in rodents and people, permitting a comparative view on similarities and modifications in several genetic version platforms. different version platforms are scrutinized within the gentle of up to date getting older speculation, equivalent to the loose radical and genomic instability theories.

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Benguria, J. M. Jazwinski, submitted). When induced, the retrograde response not only compensates for the deleterious effects of the circles, but it activates life extension processes. The retrograde response appears to possess broad significance as a metabolic mechanism determining longevity. The mitochondrial dysfunction displayed by a 44 S. Michal Jazwinski mouse model of cardiomyopathy (Li et al. 2000) may be compensated by a mechanism akin to the retrograde response in yeast, allowing the animal to survive and function almost normally for a time.

1987). It involves interorganelle communication, because the mitochondrial dysfunction causes changes in nuclear gene expression. These nuclear genes encode a variety of mitochondrial, cytoplasmic, and peroxisomal proteins (Liao et al. 1991; Small et al. 1995; Chelstowska and Butow, 1995; Vélot et al. 1996). The net effect of these changes in gene expression is a profound remodeling of cell metabolism. There is a shift from the utilization of the full Krebs cycle to the use of the glyoxylate cycle, which allows the cell to synthesize biosynthetic intermediates from acetate.

The lifespan shortening effect of elimination of Sir2p appears to be caused by the loss of silencing at the ribosomal DNA locus (Smith and Boeke 1997; Kim et al. 1999). The processes affected by Hda1p and Sir2p are not likely identical, though there could be some overlap. From the known patterns of gene expression elicited by the deletions of RPD3, HDA1, and SIR2 (Wyrick et al. 1999; Hughes et al. 2000; Bernstein et al. 2000), it was proposed that the major effectors of calorie restriction are involved in carbohydrate/energy metabolism, and in particular in mitochondrial function (Jiang et al.

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Model Systems in Aging by Thomas Nyström, Heinz D. Osiewacz


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