New PDF release: microRNA: Medical Evidence: From Molecular Biology to

By Gaetano Santulli

ISBN-10: 3319226703

ISBN-13: 9783319226705

ISBN-10: 3319226711

ISBN-13: 9783319226712

This quantity explores microRNA functionality in a wide range of human problems, delivering a medical foundation for precision drugs and customized cures utilizing those molecules. The twenty-one chapters, all authored by means of internationally-renowned specialists, open with an advent contextualizing microRNA manipulation inside of today’s projects in the direction of precision medication. the next chapters discover the scientific position of microRNAs within the analysis and therapy of metabolic and cardiovascular problems, concentrating on mitochondrial health, arterial high blood pressure, cardiovascular home improvement, cerebrovascular affliction, pulmonary high blood pressure, diabetic kidney affliction, and kidney transplantation. the following chapters talk about the significance of microRNAs within the wound therapeutic procedure and in epidermis ailment, within the pathogenesis of hypersensitivity, in human ovulation, and in an infection. The publication concludes with chapters which define the rising function of microRNAS in doping and aspect microRNA profiling.

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Additional info for microRNA: Medical Evidence: From Molecular Biology to Clinical Practice

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PLoS One. 2011;6, e23423. 35. Yu B, Zhou S, Qian T, Wang Y, Ding F, Gu X. Altered microRNA expression following sciatic nerve resection in dorsal root ganglia of rats. Acta Biochim Biophys Sin (Shanghai). 2011;43: 909–15. 36. Yu B, Zhou S, Wang Y, Ding G, Ding F, Gu X. Profile of microRNAs following rat sciatic nerve injury by deep sequencing: implication for mechanisms of nerve regeneration. PLoS One. 2011;6, e24612. 37. Zhang HY, Zheng SJ, Zhao JH, Zhao W, Zheng LF, Zhao D, Li JM, Zhang XF, Chen ZB, Yi XN.

On the other hand, miR-21 expression in the DRG was unchanged in an inflammatory pain condition induced by CFA injection (unpublished data). Conversely, serum miR-21 expression was decreased in rats after spinal nerve ligation [50]. In DRG neurons, miR-21 was found to be involved in cellular responses to neuronal damage as well as neuropathic pain. miR-21 enhanced axonal growth of DRG neurons in vitro [34] and inhibited apoptosis of cultured DRG neurons [61], suggesting that miR-21 contributes to functional recovery from nerve injury.

2010;30:1073–85. 68. Vigorito E, Kohlhaas S, Lu D, Leyland R. miR-155: an ancient regulator of the immune system. Immunol Rev. 2013;253:146–57. 69. Tan Y, Yang J, Xiang K, Tan Q, Guo Q. Suppression of MicroRNA-155 attenuates neuropathic pain by regulating SOCS1 signalling pathway. Neurochem Res. 2014;40:550–60. 70. Li X, Kroin JS, Kc R, Gibson G, Chen D, Corbett GT, Pahan K, Fayyaz S, Kim JS, van Wijnen AJ, Suh J, Kim SG, Im HJ. Altered spinal microRNA-146a and the microRNA-183 cluster contribute to osteoarthritic pain in knee joints.

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microRNA: Medical Evidence: From Molecular Biology to Clinical Practice by Gaetano Santulli


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