By Gaetano Santulli
This quantity explores microRNA pathophysiology, concentrating on simple recommendations in molecular and mobile biology. Chapters contributed via top scientists study lately chanced on pathways in different approaches, together with getting older, diabetes, heart problems, hematopoiesis, and mitochondrial health. The authors contextualize microRNAs inside epigenetics and micropeptidomics, angiongenesis and atherosclerosis, endometrial pathophysiology, and extra. all through, a variety of colour photos, diagrams of molecular pathways, and tables increase the text.
Read or Download microRNA: Basic Science: From Molecular Biology to Clinical Practice PDF
Similar basic science books
No longer male trend baldness, however the lack of sensory hair, is a really severe subject. Sensory hair cells convert sound and movement into our experience of listening to, flow, and head place. In mammals, the lack of hair cells is irreversible. Or is it? Hair cells in different vertebrates are able to regenerating and recuperating partial or whole functionality.
This interesting new reference brings you information regarding the main arguable gastroenterology and foodstuff demanding situations you face on your perform. The publication with a bit of luck tackles those matters and offers pro suggestion at the newest diagnostic and remedy options utilizing evidence-based drugs at any place attainable.
Written within the related enticing conversational variety because the acclaimed first variation, Primer to The Immune reaction, second variation is a completely up to date and worthy source for school and collage scholars in existence sciences, medication and different healthiness professions who want a concise yet complete advent to immunology.
Extra resources for microRNA: Basic Science: From Molecular Biology to Clinical Practice
Found that the loop sequence is dispensable for DROSHA processing, and that synthetic “hairpins” in which the loop is replaced by an extended duplex with open termini are easily processed . Both studies identiﬁed the importance of single-stranded RNA regions ﬂanking the base of the lower stem for recognition of the pre-miRNA by the Microprocessor complex [32, 33]. Thermodynamic analysis of hundreds of human and D. melanogaster pri-miRNA hairpins revealed that the DROSHA cleavage site is typically ~11 nucleotides (~1 helical turn) from the ssRNA–dsRNA stem junction and ~22 nucleotides (~2 helical turns) from the terminal loop, suggesting that DROSHA measures the distance from either the base of the stem or the loop in order to determine the cleavage site.
Denli AM, Tops BBJ, Plasterk RHA, Ketting RF, Hannon GJ. Processing of primary microRNAs by the microprocessor complex. Nature. 2004;432:231–5. 31. Landthaler M, Yalcin A, Tuschl T. The human DiGeorge syndrome critical region gene 8 and its D. melanogaster homolog are required for miRNA biogenesis. Curr Biol. 2004;14:2162–7. 32. Zeng Y, Yi R, Cullen BR. Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha. EMBO J. 2005;24:138–48. 33. Han J, Lee Y, Yeom K-H, Nam J-W, Heo I, Rhee J-K, Sohn SY, Cho Y, Zhang B-T, Kim VN.
Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis. Proc Natl Acad Sci U S A. 2010;107: 15163–8. 93. Schirle NT, MacRae IJ. The crystal structure of human Argonaute2. Science. 2012;336: 1037–40. 94. Elkayam E, Kuhn C-D, Tocilj A, Haase AD, Greene EM, Hannon GJ, Joshua-Tor L. The structure of human Argonaute-2 in complex with miR-20a. Cell. 2012;150:100–10. 95. Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often ﬂanked by adenosines, indicates that thousands of human genes are microRNA targets.
microRNA: Basic Science: From Molecular Biology to Clinical Practice by Gaetano Santulli