Read e-book online Medullary Thyroid Carcinoma PDF

By F. Raue, A. Zink, H. Scherübl (auth.), Prof. Dr. Friedhelm Raue (eds.)

ISBN-10: 3642847498

ISBN-13: 9783642847493

ISBN-10: 364284751X

ISBN-13: 9783642847516

Medullary Thyroid Carcinoma is an extraordinary thyroid tumor originating from neural crest cells, the C-cell that suggests numerous exact gains, secretion of alternative neuroendocrine markers, organization with different endocrine tumors and familial visual appeal. The familial version of medullary thyroid carcinoma permits an early detection by means of biochemical and genetic trying out. At that degree appropriate surgical operation will medication the sufferer. The sporadic kind of medullary thyroid carcinoma may be clinically determined in a revolutionary level, yet sufficient surgery can healing those sufferers too. long-term survival depends upon level, age, intercourse, and variation of the affliction and seems nearly as good as in different differentiated thyroid cancers.

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1989). As has been noted by LiVolsi (1990) it is possible that malignant variants of this tumour will be described in the future. Pathology of Sporadic and Hereditary Medullary Thyroid Carcinoma 39 As far as non-encapsulated neoplasms are concerned, the abovementioned broad spectrum of histological variants of MTC infers that C-cell carcinoma may not only resemble all other types of primary thyroid cancer, but can also mimic carcinoma metastatic to the thyroid. It is thus essential that whenever a pathologist is faced with a thyroid lesion which is atypical in appearance or when not all the criteria for a particular diagnosis are present, immunostaining for both TG and CT be performed to help arrive at a definitive diagnosis (LiVolsi 1990).

It seems impossible that one could define a tumour as MTC if it were negative for CT, the specific product of C-cells. Since the introduction of immunolocalization techniques, most authors have considered CT positivity to be the prerequisite for diagnosing this condition. Thus, 265 of 266 immunocytochemically investigated cases communicated until 1988 were reported to be positively stained (DeLellis et al. 1978; Talerman et al. 1979; Wolfe et al. 1980; Lloyd et al. 1983; Saad et al. 1984b; Holm et al.

Hornig, Miinster; F. S. Keck, Ulm; I.

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Medullary Thyroid Carcinoma by F. Raue, A. Zink, H. Scherübl (auth.), Prof. Dr. Friedhelm Raue (eds.)


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