By Mary Hendrix
This e-book represents the 1st compilation of the main learn findings relating to Maspin—a mammary serpin (or serine) protease inhibitor. Maspin used to be initially chanced on via subtractive hybridization and differential reveal analyses, evaluating the variations in gene expression in general mammary epithelium and invasive carcinoma cells. This paintings originated within the laboratory of Dr. Ruth Sager, a world-renowned geneticist, on the Dana Farber melanoma Institute and Harvard clinical tuition. the 1st creation of Maspin to the learn neighborhood happened as a document in technological know-how (v263:526-529, 1994), and defined the original tumor-suppressing job of this novel gene in human mammary epithelial cells.
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Additional info for Maspin
Since maspin is both a proteinase inhibitor, a locomotion inhibitor and an angiogenesis inhibitor, the diverse actions of maspin may largely explain the pronounced anti-invasive and anti-angiogenic effects of myoepithelial cells on carcinoma and pre-carcinoma cells. The same actions of maspin also may account for the low grade biology of myoepithelial tumors which are devoid of appreciable angiogenesis and invasive behavior. C. Hendrix. com Maspin and Myoepithelial Cells 31 ductal-lobular units of the mammary and salivary glands respectively.
2C). The HMS-1 line was itself non-invasive in this chamber. Predictably, the anti-invasive effects of HMS-1 could be abolished by CHX (40 ∝g/ml) 24 hr pretreatment. 01). 25 ∝M) produced a complete invasion-permissive phenotype (100% of control) whereas 40 Maspin Fig. 2B. Myoepithelial-related immunoreactivity in situ. * myoepithelial cells; ‡ epithelial cells; § ++++, intensely positive; +++, strongly positive;++, positive; +, weakly positive; ±, equivocally positive; -, negative. 05) (Fig. 2D).
The role of conformational change in serpin structure and function. Bioessays 1993; 15(7):461-467. 30. Pemberton PA, Wong DT, Gibson HL, Kiefer MC, Fitzpatrick PA et al. The tumore suppressor maspin does not undergo the stressed to relaxed transition or inhibit trypsinlike serine proteinases. Evidence that maspin is not a protease inhibitory serpin. J Biol Chem 1995; 270(26):15832-15837. 31. Potempa J, Shieh BH, Travis J. Alpha-2-antiplasmin: A serpin with two separate but overlapping reactive sites.
Maspin by Mary Hendrix