Download PDF by Christian Barbato, Francesca Ruberti: Mapping of nervous system diseases via MicroRNAs

By Christian Barbato, Francesca Ruberti

ISBN-10: 148226353X

ISBN-13: 9781482263534

In fresh years, figuring out of microRNA (miRNA) biogenesis, the molecular mechanisms wherein miRNAs keep an eye on gene expression, and the useful roles of miRNAs has accelerated. Mapping of fearful method ailments through MicroRNAs presents an up to date evaluation at the functionality of miRNA in neurological ailments in addition to developments in know-how for healing modulation of miRNA activity.

MicroRNAs are small RNA molecules that keep an eye on gene expression post-transcriptionally. A turning out to be physique of proof means that miRNAs are dysregulated in different neurological issues. as well as reviewing common ideas and novel insights on mind functionality on the subject of miRNA, this booklet additionally examines the position of miRNA in:

  • Neurological diseases
  • Neurodegenerative diseases
  • Neuropsychiatric diseases
  • Neurodevelopmental diseases

The publication additionally discusses the importance of miRNAs as diagnostic instruments, biomarkers, brokers, and goals within the detection and remedy of neurological illnesses. each one bankruptcy comprises fabric concerning destiny diagnostic and healing advances.

Molecular and mobile neurobiological stories of miRNA-mediated gene silencing within the worried method have opened new frontiers for the improvement of latest diagnostic checks and genetic cures for neurological ailments. masking the entire variety of appropriate recommendations and giving a glance into current and destiny percentages, Mapping of frightened approach illnesses through MicroRNAs is an important state of the art reference for neurologists, neuropathologists, and researchers and practitioners in a variety of comparable fields.

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Fragile X mental retardation protein induces synapse loss through acute postsynaptic translational regulation. J Neurosci 27:3120–30. Remenyi J, van den Bosch MW, Palygin O, Mistry RB, McKenzie C, Macdonald A, Hutvagner G, Arthur JS, Frenguelli BG, Pankratov Y. 2013. miR-132/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity. PLoS One 8:e62509. Ruberti F, Barbato C, Cogoni C. 2012. Targeting microRNAs in neurons: Tools and perspectives. Exp Neurol 235:419–26.

2 Clinical Studies.................................................................................... 1 Clinical Studies in BPAD..................................................... 3 Postmortem Studies.............................................................. 4 Peripheral Tissue Studies...................................................... 3 Summary............................................................................................. 7 Review of MicroRNAs and Anxiety Disorders...............................................

2 Clinical Studies in Depression Our systematic review identified 15 articles that were relevant for inclusion. Research investigating the role of miRNA involvement in depressive disorder is rapidly MicroRNAs in Mood and Anxiety Disorders 41 gathering pace with a number of clinical studies in recent years. , 2014a,b). Others have focused on peripheral sources of miRNA, typically in the search of a biomarker for depression. , 2015). , 2014). 4 and expanded upon below. , 2012). Using multiplex PCR, the authors found a downregulation of 21 miRNAs.

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Mapping of nervous system diseases via MicroRNAs by Christian Barbato, Francesca Ruberti


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