Alejandro Corvalan, Ignacio I. Wistuba (auth.), David J.'s Lung Cancer: Prevention, Management, and Emerging Therapies PDF

By Alejandro Corvalan, Ignacio I. Wistuba (auth.), David J. Stewart (eds.)

ISBN-10: 1607615231

ISBN-13: 9781607615231

This complete source offers authoritative wisdom of the main updated prevention and remedy options for thoracic malignancies. confirmed and investigational remedies are put within the context of tumor biology for an entire figuring out of the pharmacogenetics, etiology, and altering epidemiology of lung melanoma. professional clinicians aspect the functionality of predictive and prognostic components within the usage of chemo-radiotherapy, adjuvant and neoadjuvant therapy, and distinctive brokers. the guarantees and capability pitfalls of investigational suggestions are evaluated with unprecedented perception and readability, with targeted cognizance paid to the mechanisms of drug resistance and goals for lung melanoma remedy and prevention. Lung melanoma: Prevention, administration, and rising remedies engages the total spectrum of healing modalities with specialise in systemic ways. illness assurance comprises newly clinically determined and recurrent non-small phone lung melanoma, small cellphone carcinoma, and mesothelioma. serious exam of the influence, technique, and layout of scientific trials is gifted besides new paradigms for custom-made ways and person hazard assessment.

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Extra info for Lung Cancer: Prevention, Management, and Emerging Therapies

Example text

Several recent publications suggest that these discrepancies may reflect differences in the number, grade, stage, and size of tumors included in each study, all of which varied considerably across the studies. The lack of consensus both within and between tumor types may also be related to the diverse approaches used to assess the infiltrates. For example, in two publications by Chen and colleagues, tumor-associated macrophage density correlated with poor prognosis in NSCLC, but macrophages within the tumor and those in the adjacent stroma were counted together (13, 14).

Potti A, Mukherjee S, Petersen R et al (2006) A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer. N Engl J Med 355:570–580 101. Chen HY, Yu SL, Chen CH et al (2007) A five-gene signature and clinical outcome in nonsmall-cell lung cancer. N Engl J Med 356:11–20 102. Oshita F, Sekiyama A, Saito H, Yamada K, Noda K, Miyagi Y (2006) Genome-wide cDNA microarray screening of genes related to the benefits of paclitaxel and irinotecan chemotherapy in patients with advanced non-small cell lung cancer.

Altaha R, Liang X, Yu JJ, Reed E (2004) Excision repair cross complementing-group 1: gene expression and platinum resistance. Int J Mol Med 14:959–970 86. Simon GR, Sharma S, Cantor A, Smith P, Bepler G (2005) ERCC1 expression is a predictor of survival in resected patients with non-small cell lung cancer. Chest 127:978–983 87. Zheng Z, Chen T, Li X, Haura E, Sharma A, Bepler G (2007) DNA synthesis and repair genes RRM1 and ERCC1 in lung cancer. N Engl J Med 356:800–808 88. Lord RV, Brabender J, Gandara D et al (2002) Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell lung cancer.

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Lung Cancer: Prevention, Management, and Emerging Therapies by Alejandro Corvalan, Ignacio I. Wistuba (auth.), David J. Stewart (eds.)


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