Get Introduction to proteins : structure, function, and motion PDF

By Amit Kessel

ISBN-10: 1439810710

ISBN-13: 9781439810712

Because the instruments and methods of structural biophysics suppose larger roles in organic study and various software components, studying how proteins behave turns into an important to figuring out their connection to the main simple and critical elements of existence. With greater than 350 colour photos all through, advent to Proteins: constitution, functionality, and movement provides a unified, in-depth therapy of the connection among the constitution, dynamics, and serve as of proteins. Taking a structural–biophysical process, the authors talk about the molecular interactions and thermodynamic alterations that transpire in those hugely complicated molecules. The textual content contains numerous biochemical, actual, useful, and clinical points. It covers assorted degrees of protein constitution, present equipment for constitution decision, energetics of protein constitution, protein folding and folded nation dynamics, and the features of intrinsically unstructured proteins. The authors additionally make clear the structure–function courting of proteins via featuring the rules of protein motion within the kind of instructions. This complete, colour publication makes use of various proteins as examples to demonstrate the subjects and ideas and to teach how proteins might be analyzed in a number of methods. It refers to many daily purposes of proteins and enzymes in clinical problems, medicines, pollutants, chemical battle, and animal habit. Downloadable questions for every bankruptcy can be found at CRC Press on-line.

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Extra resources for Introduction to proteins : structure, function, and motion

Example text

The blue plot depicts a chemical reaction, in which a hypothetical reactant (A) is transformed into a product (B) (see the top right part of the figure). The reaction involves a transition state (A#), which is higher in energy than the reactant by ΔE#. In the presence of an enzyme (En), the reaction path changes; the enzyme binds to the reactant rapidly, transforms it into the product, and releases the latter (the red dashed plot). Since the energy difference between reactant and product (ΔER) remains the same, the overall energetics of the reaction do not change.

The reaction involves a transition state (A#), which is higher in energy than the reactant by ΔE#. In the presence of an enzyme (En), the reaction path changes; the enzyme binds to the reactant rapidly, transforms it into the product, and releases the latter (the red dashed plot). Since the energy difference between reactant and product (ΔER) remains the same, the overall energetics of the reaction do not change. However, in the enzyme-catalyzed reaction, the transition state is much lower in energy (ΔE#2) than in the uncatalyzed reaction.

The first is the functional activation of a molecule. This mode of action is very common in the activation of other enzymes during hormone-mediated signal transduction. The second use of phosphorylation is to destabilize a molecule, in order to make it a better substrate for a subsequent reaction. , the pentose–phosphate pathway[41]). Enzymes catalyzing phosphate/phosphonate-transfer reactions are often called by their traditional names: kinase and phosphorylase. Kinases transfer a phosphonate group from a high-energy molecule, usually ATP, to an acceptor.

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Introduction to proteins : structure, function, and motion by Amit Kessel


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