By Kwang W. Jeon, Jonathan Jarvik
International assessment of Cytology offers present advances and complete reports in phone biology-both plant and animal. Articles handle constitution and regulate of gene expression, nucleocytoplasmic interactions, keep watch over of mobile improvement and differentiation, and telephone transformation and development. Authored by means of many of the most suitable scientists within the box, each one quantity offers updated details and instructions for destiny study.
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Extra info for International Review of Cytology, Vol. 159
The Blood-Brain Barrier and Circumventricular Organs in Hypothalamic Integration of Neuronal Information and Synthesis and Transfer of Neurohormones Development, aging, and senescence of the hypothalamic nuclei are closely related to the specificities of their organization, localization, and communication via the primary and secondary BBB. The ultrastructure of blood-brain and blood-CSF barriers in relation to similar noncerebral endothelium and epithelium was reviewed by Van Deurs (1980), who emphasized the importance of the basement lamina and phagocytic pericytes in the BBB.
1986). All the neurons that terminate outside of the blood-brain barrier, that is, in the primary barrier comprising the CVOs were identified. , 1984). The arcuate dopaminergic neuronal bodies have estrogen receptors. There is evidence that dopaminergic neurons can interact with LRH terminals in the median eminence and that hypothalamic dopaminergic networks have a role in controlling hypothalamic neurons and secretion of pituitary cells. Subsequent to the isolation and purification of LRH and elucidation of the amino acid sequence of this decapeptide, numerous analogs have been synthesized that are more potent than LRH in releasing LH and FSH.
The release of LRH to general and portal circulation is highest during neonatal development in both of these circumventricular organs (Ugrumov, 1991). As is known, androgen and estrogen of endogenous origin from gonads, or exogenously administered during the perinatal period, may permanently masculinize and defeminize neurons involved in controlling sexually dimorphic brain neurons. Male rats that are castrated perinatally are demasculinized in adulthood after treatment with testosterone. The estrogen may act indirectly via the estrogen receptor-containing neurons and/or directly by neurons of the medial preoptic area that incorporate estrogen.
International Review of Cytology, Vol. 159 by Kwang W. Jeon, Jonathan Jarvik