Earl Brown's Integrated Basic Sciences: PreTest Self-Assessment and PDF

By Earl Brown

ISBN-10: 007052551X

ISBN-13: 9780070525511

This new Pre-test name deals one more device for USMLE prep. This time, the fundamental technological know-how questions are built-in simply as they're at the USMLE Step 1 examination. 151 medical vignettes also are incorporated and bolstered what is confirmed at the examination. All solutions are referenced to the present literature for these desirous to extend their examine.

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Fanconi’s anemia is a rare familial form of aplastic anemia that is characterized by multiple congenital anomalies, including hypoplasia of the kidney and spleen, and hypoplastic anomalies of the bones, particularly involving the thumbs or radii. Most of the acquired cases of aplastic anemia have no known cause; that is, they are idiopathic. Know causes of aplastic anemia include stem cell injury from chemical agents, whole-body radiation, and infections. Drugs are the most common cause of secondary aplastic anemia.

Patients will characteristically have a cherry-red color to their skin and blood. In contrast, patient’s with an abnormal hemoglobin that has decreased CHAPTER 1 HEMATOLOGY 39 oxygen affinity will present with cyanosis, and their hemoglobin – oxygen dissociation curve will be shifted to the right (increased P50). Answers to Case Study V 13. The answer is E. (Gartner, 1/e, p 189. ) Hemoglobin is a protein composed of four heme groups bound to four polypeptide globin chains. There are several different types of globin chains, and the types of globin chains that are present determine the particular type of hemoglobin that is formed.

The proteins of the RBC membrane are located either within the membrane (integral proteins), or they are 34 INTEGRATED BASIC SCIENCES attached to the inner surface of the membrane (peripheral proteins). Examples of integral proteins, which span the RBC membrane, include protein 3 (protein C) and the glycophorins. Protein 3 forms the anionexchange channel, which is responsible for the exchange of chloride and bicarbonate ions. ” There are several types of glycophorins. Glycophorin A, which is responsible for the MN blood types, is the binding site of plasmodium falciparum and the influenza virus.

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Integrated Basic Sciences: PreTest Self-Assessment and Review by Earl Brown


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