New PDF release: Insertional Mutagenesis Strategies in Cancer Genetics

By Anton Berns (auth.), Adam J. Dupuy, David A. Largaespada (eds.)

ISBN-10: 1441976558

ISBN-13: 9781441976550

ISBN-10: 1441976566

ISBN-13: 9781441976567

Over the earlier a long time, insertional mutagenesis has performed an immense contribution to our figuring out of melanoma. first and foremost, the motion of sluggish reworking retroviruses was once used to spot endogenous mobile oncogenes (e.g. Myc, Myb). those observations sparked a sequence of experiments that finally resulted in the belief melanoma is because of somatically bought mutations in endogenous oncogenes and tumor suppressor genes. seeing that those discoveries, insertional mutagenesis has been used to spot novel melanoma genes in a number of tumor forms in animal versions of melanoma. more moderen paintings has constructed novel insertional mutagens, equivalent to transposons, that experience broader features to version melanoma in vivo. whereas this paintings has concerned about constructing animal types of melanoma, fresh gene treatment trials in human sufferers have proven that insertional mutagenesis may also give a contribution to transformation. The aim of this paintings is summarize the contribution that insertional mutagenesis has made to our figuring out of melanoma. various insertional mutagens are provided which were used to check numerous tumor varieties in numerous version organisms. furthermore, the impression of insertional mutagenesis in numerous gene treatment trials is mentioned besides ideas to prevent such problems in destiny scientific trials.

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Additional resources for Insertional Mutagenesis Strategies in Cancer Genetics

Example text

Cancer Research, 69, 431–439. 76. , & Davidson, W. (1991). Acute myeloid leukemia induction by amphotropic murine retrovirus (4070A): Clonal integrations involve c-myb in some but not all leukemias. Journal of Virology, 65, 3607–3616. 77. , & Anver, M. R. (2003). A Moloney murine leukemia virus-based retrovirus with 4070A long terminal repeat sequences induces a high incidence of myeloid as well as lymphoid neoplasms. Journal of Virology, 77, 4965–4971. 78. , Luke, B. , & Burgess, S. M. (2006).

77. , & Anver, M. R. (2003). A Moloney murine leukemia virus-based retrovirus with 4070A long terminal repeat sequences induces a high incidence of myeloid as well as lymphoid neoplasms. Journal of Virology, 77, 4965–4971. 78. , Luke, B. , & Burgess, S. M. (2006). Redefining the common insertion site. Virology, 344, 292–295. 79. , Valk, P. , Wallace, M. , Loh, M. , Shannon, K. , et al. (2009). A retroviral mutagenesis screen reveals strong cooperation between Bcl11a overexpression and loss of the Nf1 tumor suppressor gene.

Berns, A. (2009). High-throughput insertional mutagenesis screens in mice to identify oncogenic networks. Nature Review Cancer, 9, 389–399. 31. , et al. (2007). Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia. Nature Genetics, 39, 593–595. 32. Landrette, S. , Kuo, Y. , Perrat, P. , Van de Ven, W. , et al. (2005). Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with CbfbMYH11. Blood, 105, 2900–2907. 33. Largaespada, D. , Brannan, C. , Jenkins, N.

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Insertional Mutagenesis Strategies in Cancer Genetics by Anton Berns (auth.), Adam J. Dupuy, David A. Largaespada (eds.)


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