Immunology and immunopathogenesis of malaria - download pdf or read online

By 0, Jean Langhorne

ISBN-10: 3540257187

ISBN-13: 9783540257189

ISBN-10: 354029967X

ISBN-13: 9783540299677

Malaria continues to be an enormous international ailment, killing greater than 1 million humans each year. just about all of those deaths are brought on by Plasmodium falciparum, one of many 4 species of malaria parasites infecting people. This excessive burden of mortality falls seriously on Sub-Saharan Africa, the place over ninety% of those deaths are concept to happen, and five% of kids die ahead of the age of five years. The dying toll from malaria remains to be starting to be, with malaria-specific mortality in younger African kids anticipated to have doubled over the last two decades. This elevate has been linked to drug resistance of the parasite, unfold of insecticide resistant mosquitoes, poverty, social and political upheaval, and absence of potent vaccines. This selection of stories addresses a lot of those vital problems with malarial immunity and immunopathology. they're of curiosity not just to malariologists, yet with a bit of luck additionally to the wider immunological neighborhood. robust interactions with, and suggestions from immunologists operating in different infectious illnesses and in simple immunology can help us to maneuver the sector of malaria immunology and healing intervention ahead extra speedy.

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Extra info for Immunology and immunopathogenesis of malaria

Example text

6 Innate Immune Responses to Plasmodium Blood-Stage Infection in Mice . . . . . Mouse Models of Malaria . . . . . . Dendritic Cells . . . . . . . . . . Macrophages . . . . . . . . . . . γδ T Cells . . . . . . . . . . . . Interactions Between DC and NK Cells . . Cytokine Production by APC . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

During the innate immune response to Plasmodium infection, DCs may express several cytokines, including IL-2, IL-12, IFN-γ and, in humans, IFN-α (Fig. 2) [47, 94, 124]. Some of these type 1 cytokines are known to activate macrophages and NK cells to secrete cytokines and to become phagocytic and/or cytolytic [4, 57, 165].

1992) Distinct T cell specificities are induced with the authentic versus recombinant Plasmodium berghei circumsporozoite protein. J Immunol 148:2530–2538 56. Krzych U, Schwenk R, Guebre-Xabier M, et al. (2000) The role of intrahepatic lymphocytes in mediating protective immunity induced by attenuated Plasmodium berghei sporozoites. Immunol Rev 174:123–134 57. Ku CC, Murakami M, Sakamoto A, et al. (2000) Control of homeostasis of CD8+ memory T cells by opposing cytokines. Science 288:675–678 58.

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Immunology and immunopathogenesis of malaria by 0, Jean Langhorne

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