By Keith J.
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Huang, L. Inhibition of human ovarian carcinoma cell proliferation by liposome–plasmid DNA complex. Biochem. Biophys. Res. Commun. 207(2): 492– 6, 1995. E. Direct gene transfer with DNA–liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans. Proc. Natl. Acad. Sci. USA 90(23): 11307–11, 1993. , Gilboa, E. Efﬁcient gene transfer with adenoassociated virus-based plasmids complexed to cationic liposomes for gene therapy of human prostate cancer. Cancer Res. 55(1l): 2366–72, 1995.
71(3): 387–91, 1994. , Matsuo, N. Gene transfer with liposomes to the intraocular tissues by different routes of administration. Invest. Ophthalmol. Vis. Sci. 37(9): 1914–20, 1996. , Matsuo, N. Gene transfer to the retina of rat by liposome eye drops. Biochem. Biophys. Res. Commun. 219(3): 947–50, 1996. L. No lung toxicity after repeated aerosol or intravenous delivery of plasmid-cationic liposome complexes. J. App. Physiol. 77(1 ): 415–19, 1994. , Caplen. , Hurt. , Williamson, R. et al. Non-invasive 12 52 53 54 55 56 57 58 59 60 61 62 63 64 GENE THERAPY TECHNOLOGIES, APPLICATIONS AND REGULATIONS liposome-mediated gene delivery can correct the ion transport defect in cystic ﬁbrosis mutant mice.
Cationic liposomes have also been used to inhibit intimal smooth muscle proliferation (such as by delivery of E2F binding site decoys) for in vivo studies of rat carotid injury (43,44) or to deliver genes encoding interleukin-10 (IL-10) or domains of the human tumor necrosis factor alpha (TNF ) receptor to mitigate lethal endotoxemia in mice (45). Liposome-mediated expression of the luciferase gene in pig coronary arteries could be augmented further by activation of vascular cell proliferation.
IL-11 Receptor by Keith J.