Read e-book online Human Sleep and Cognition Part IIClinical and Applied PDF

By Hans P.A. Van Dongen and Gerard A. Kerkhof (Eds.)

ISBN-10: 0444538178

ISBN-13: 9780444538178

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2009). Importantly, these data suggest that promotion of NREM sleep offers a target for interventions that may result in more effective encoding and consolidation of memories. , napping, exercise). Unfortunately, to date, there have only been a few studies conducted in older adults with neurodegenerative disease that have examined in detail the role of sleep stages for optimal memory encoding or consolidation. , 2008). Data also suggest that there is a reduction in prefrontal sleep spindles with age (De Gennaro and Ferrara, 2003).

2008). Overall, however, further research utilizing melatonin and melatonin agonists is required in order to determine their efficacy, safety, and suitability for older at-risk patients as well as those with established neurodegenerative diseases. , ramelteon). However, despite their frequent use, few data are available regarding their longterm safety and efficacy (see review by Krystal, 2010), nor are detailed data available regarding effects on cognition. A relatively small number of studies have used PSG to examine effects on sleep architecture and there is a dearth of studies that included other outcomes, particularly mood, cognition, and functional status (see Krystal, 2010).

Nocturnal onset of melatonin secretion is temporally related to a decrease in core body temperature, reduction in alertness and cognitive function, and increased sleep propensity (Wright and Rogers, 2008). , 2003a). , 2001; Touitou, 2001). , 1999). , foods containing high levels of tryptophan or melatonin) are known to influence melatonin production and thus may potentially contribute to sleep–wake disturbance in older adults. Currently, there is a dearth of data that has investigated the dynamic interplay between sleep–wake changes that occur with aging and age-associated changes in cognitive functioning.

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Human Sleep and Cognition Part IIClinical and Applied Research by Hans P.A. Van Dongen and Gerard A. Kerkhof (Eds.)

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