Download PDF by Richard Champlin: Hematopoietic Stem Cell Transplantation

By Richard Champlin

ISBN-10: 0203908031

ISBN-13: 9780203908037

ISBN-10: 0585365059

ISBN-13: 9780585365053

ISBN-10: 0824702735

ISBN-13: 9780824702731

ISBN-10: 0824741811

ISBN-13: 9780824741815

This e-book integrates contemporary advances in molecular and cellphone biology of hematopoietic stem cells (HSC) with advancements in scientific examine in stem cell-based therapy-providing an updated evaluation of novel cytokines and mobile elements; animal versions; mobile training, choice, and assortment; minimum residual illness and purging; growth of progenitor cells; allogeneic and autologous transplantation; mobile gene and immunotherapy; and extra. Examines key components for remedy with HSC, together with ambulatory care and tracking, regimen-related toxicities, immunodeficiency and immunization, an infection, continual graft-versus-host and illness, secondary malignancies, and long term caliber of existence. protecting stem mobilephone pool rules and the complicated interaction of extrinsic and intrinsic occasions, Hematopoietic Stem mobilephone Transplantation ·summarizes present figuring out and improvement of scientific allogeneic HSC transplantation ·discusses using allogeneic transplantations with decreased conditioning routine or mini-transplantation ·considers a variety of ideas for mobilization of HSCs from peripheral blood (PB) of standard donors ·details detection of bone marrow infection via tumor cells and removing methods ·focuses on efforts to extend the ex vivo transduction potency of human HSCs with retroviral vectors ·explores the consequences of development issue management and leukapheresis on PB stem phone donors ·shows the effect of CD34+ telephone isolation and the relevance of growth of HSC from bone marrow for medical use ·reveals how minimum residue sickness detection assays are an important for monitoring the medical importance of infused tumor cells ·employs computerized fluorescence picture cytometry to check early HSC habit following seeding Incorporating contributions from over ninety researchers who cite greater than 2180 references to inspire endured research, Hematopoietic Stem telephone Transplantation is a blue-chip reference for hematologists, hematopathologists, oncologists, cytotherapists, transplantation immunologists, and molecular biologists.

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Extra resources for Hematopoietic Stem Cell Transplantation

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Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro. Blood 1995; 85:1719–1726. Broudy VC, Lin NL, Fox N, Taga T, Saito M, Kaushansky K. Thrombopoietin stimulates colony-forming unit-megakaryocyte proliferation and megakaryocyte maturation independently of cytokines that signal through the gp 130 receptor subunit. Blood 1996; 88:2026– 2032. Zucker FD, Kaushansky K.

Broxmeyer HE, Lu L, Cooper S, Ruggieri L, Li ZH, Lyman SD. Flt3 ligand stimulates costimulates the growth of myeloid stem/progenitor cells. Exp Hematol 1995; 23:1121–1129. 17. McKenna HJ, deVries P, Brasel K, Lyman SD, Williams DE. Effect of flt3 ligand on the ex vivo expansion of human CD34 ϩ hematopoietic progenitor cells. Blood 1995; 86:3413–3420. 18. Petzer AL, Hogge DE, Landsdrop PM, Reid DS, Eaves CJ. Self-renewal of primitive human hematopoietic cells (long-term-culture-initiating cell) in vitro and their expansion in defined medium.

5. Lyman SD, James L, Zappone J, Sleath PR, Beckmann MP, Bird T. Characterization of the protein encoded by the flt3/flk2 receptor–like tyrosine kinase gene. Oncogene 1993; 8:815– 822. 6. Zeigler FC, Bennett BD, Jordan CT, Spencer SD, Baumhueter S, Carroll KJ, Hooley J, Bauer K, Matthews W. Cellular and molecular characterization of the role of the flt3/flk2 receptor tyrosine kinase in hematopoietic stem cells. Blood 1994; 84:2422–2430. 7. Rask JEJ, Metcalf D, Rossner MT, Begley CG, Nicola NA. The flt3/flk2 ligand: receptor distribution and action on murine hemopoietic cell survival and proliferation.

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Hematopoietic Stem Cell Transplantation by Richard Champlin


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