By Comitee on EPA's exposure and human health
Even if the U.S. Environmental defense company provided a complete evaluation of the medical literature in its 2003 draft reassessment of the dangers of dioxin, the enterprise didn't sufficiently quantify the uncertainties and variabilities linked to the dangers, nor did it competently justify the assumptions used to estimate them, in accordance with this new record from the nationwide Academies and nationwide examine Council. The committee that wrote the file instructed that EPA re-estimate the dangers utilizing numerous diversified assumptions and higher converse the uncertainties in these estimates. The organisation additionally may still clarify extra truly the way it selects either the knowledge upon which the reassessment relies and the tools used to investigate them.
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Extra info for Health Risks from Dioxin and Related Compounds
The committee recommends that EPA add a section or paragraph to its Reassessment on the immunotoxicology of TCDD, other dioxins, and DLCs in the context of the biological mechanisms responsible for health effects relevant to assessing the likelihood of such effects occurring in humans at relatively low levels of exposure. The Copyright © National Academy of Sciences. All rights reserved. html PUBLIC SUMMARY 7 risk characterization should provide some insight about the level of risk given actual exposures.
Such a database should include clear requirements of data quality and traceability (chemical analysis, representative and targeted sampling, representative of consumer exposure, presentation of data, and handling and presentation of “nondetects”). Chapter 4 provides several additional recommendations about the exposure assessment section of the 2003 Reassessment. IMMUNOTOXICITY OF TCDD, OTHER DIOXINS, AND DLCS TCDD, other dioxins, and DLCs have well-known effects on the immune systems of experimental animals.
S. Environmental Protection Agency (EPA), asked the National Research Council (NRC) of the National Academies to review its 2003 draft document titled Exposure and Human Health Reassessment of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and Related Compounds (the Reassessment). This NRC report describes the Reassessment as very comprehensive in its review and analysis of the extensive scientific literature on TCDD, other dioxins, and DLCs. However, the NRC report finds substantial room for improvement in the quantitative approaches used by EPA to characterize risks.
Health Risks from Dioxin and Related Compounds by Comitee on EPA's exposure and human health